HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SHD (Q96IW2)
SH2 domain-containing adapter protein D
Gene: SHD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	9315092
Identification Methods	two hybrid, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 340
+	Hs
		337329 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRC_HUMAN (93-340): 1.58e-54: 188: 17.51
+	Hs
		337315 ABL1_HUMAN (1-1130): 0: 984: 100.00		HCK_HUMAN (103-340): 1.42e-53: 185: 19.20
+	Hs
		337483 ABL1_HUMAN (1-1130): 0: 984: 100.00		SHB_HUMAN (56-339): 2.52e-53: 184: 41.09
+	Hs
		337307 ABL1_HUMAN (1-1130): 0: 984: 100.00		FYN_HUMAN (168-340): 2.04e-51: 180: 20.56
+	Hs
		337337 ABL1_HUMAN (1-1130): 0: 984: 100.00		NCK1_HUMAN (4-336): 5.26e-53: 180: 16.58
+	Hs
		337440 ABL1_HUMAN (1-1130): 0: 984: 100.00		BTK_HUMAN (46-339): 5.73e-48: 172: 16.51
+	Hs
		337491 ABL1_HUMAN (1-1130): 0: 984: 100.00		SHE_HUMAN (112-335): 1.26e-44: 161: 41.70
+	Hs
		337384 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL2_HUMAN (152-337): 2.96e-41: 155: 26.18
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (181-338): 1.9e-44: 153: 22.01
+	Hs
		337293 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL1_HUMAN (152-339): 2.1e-39: 150: 24.23
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (181-338): 1.9e-44: 153: 22.01
+	Mm
		337637 ABL1_MOUSE (1-1130): 0: 901: 85.00		NCK1_MOUSE (4-336): 7.31e-53: 180: 16.30
+	Hs
		337466 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP_HUMAN (212-324): 2.81e-20: 89.4: 22.81
+	Hs
		275157 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP2_HUMAN (211-321): 5.36e-19: 88.3: 27.03
+	Mm
		337615 ABL1_MOUSE (1-1130): 0: 901: 85.00		ABL1_MOUSE (152-339): 2.65e-39: 149: 24.23
+	Hs
		522840 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC_HUMAN (93-340): 1.58e-54: 188: 17.51
+	Hs
		209001 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK2_HUMAN (4-335): 5.61e-55: 185: 15.45
+	Hs
		442789 ABL2_HUMAN (10-1130): 0: 775: 52.62		HCK_HUMAN (103-340): 1.42e-53: 185: 19.20
+	Hs
		412070 ABL2_HUMAN (10-1130): 0: 775: 52.62		FYN_HUMAN (168-340): 2.04e-51: 180: 20.56