Protein: HYEP
Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH)

Gene: HYEP, EPHX1
Organism: Homo sapiens
Interactions: 85
UniProt ID: P07099

Gene Ontology (top 5):
GO:0004301 - epoxide hydrolase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006805 - xenobiotic metabolic process
GO:0008142 - oxysterol binding
GO:0009636 - response to toxic substance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

421368

SRPRB
Signal recognition particle receptor subunit beta

3

0

High-throughput

0.638

High

421345

KCNS3
Potassium voltage-gated channel subfamily S member 3

2

2

High-throughput

0.574

High

421361

PCDGG
Protocadherin gamma-B4

2

4

High-throughput

0.574

High

421367

PCDG5
Protocadherin gamma-A5

2

4

High-throughput

0.574

High

421307

PE2R3
Prostaglandin E2 receptor EP3 subtype

2

2

High-throughput

0.558

High

421297

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.536

High

421355

CP26B
Cytochrome P450 26B1

1

1

High-throughput

0.536

High

226274

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.533

High

421295

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

421319

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

421328

SHSA2
Protein shisa-2 homolog

1

0

High-throughput

0.513

High

421346

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.513

High

421347

DERL1
Derlin-1

1

0

High-throughput

0.513

High

421354

RTN4
Reticulon-4

1

0

High-throughput

0.513

High

421292

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

421314

ACHD
Acetylcholine receptor subunit delta

1

1

High-throughput

0.489

High

421317

KCNC3
Potassium voltage-gated channel subfamily C member 3

1

2

High-throughput

0.489

High

421364

PCDB3
Protocadherin beta-3

1

4

High-throughput

0.489

High

421365

PCDGL
Protocadherin gamma-C4

1

4

High-throughput

0.489

High

421366

PCDGH
Protocadherin gamma-B5

1

4

High-throughput

0.489

High

421340

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

1

High-throughput

0.479

High

421309

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

421320

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

421338

RN139
E3 ubiquitin-protein ligase RNF139

1

0

High-throughput

0.458

High

397722

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.437

High

421360

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

1

High-throughput

0.437

High

421323

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

199860

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.347

High

421343

TSN17
Tetraspanin-17

3

0

High-throughput

0.347

High

421315

TRAF1
TNF receptor-associated factor 1

2

0

High-throughput

0.328

High

421337

MFSD8
Major facilitator superfamily domain-containing protein 8

2

0

High-throughput

0.328

High

421311

EVA1C
Protein eva-1 homolog C

2

0

High-throughput

0.318

High

421321

EREP1
Endosomal transmembrane epsin interactor 1

2

0

High-throughput

0.318

High

421349

RAB34
Ras-related protein Rab-34

2

0

High-throughput

0.318

High

421356

CC50A
Cell cycle control protein 50A

2

0

High-throughput

0.318

High

49440

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

208087

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.279

Low

421301

PTAFR
Platelet-activating factor receptor

1

0

High-throughput

0.279

Low

421306

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.279

Low

421313

GABT
4-aminobutyrate aminotransferase, mitochondrial

1

0

High-throughput

0.279

Low

421318

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.279

Low

421324

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

421325

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

421335

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

421336

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

421339

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

421341

OPTN
Optineurin

1

0

High-throughput

0.279

Low

421342

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

421348

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

421350

NMUR2
Neuromedin-U receptor 2

1

0

High-throughput

0.279

Low

421351

RXFP1
Relaxin receptor 1

1

0

High-throughput

0.279

Low

421352

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.279

Low

421353

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

421357

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

421358

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

421362

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

421333

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.269

Low

421300

BDNF
Brain-derived neurotrophic factor

1

0

High-throughput

0.268

Low

167805

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

204934

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

377010

GCR
Glucocorticoid receptor

1

0

Small-scale

0.249

Low

421294

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

421296

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

421298

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.249

Low

421299

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.249

Low

421302

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.249

Low

421303

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

421304

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

421305

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

421308

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

Small-scale

0.249

Low

421310

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

421312

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

421316

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

421322

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

421326

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.249

Low

421327

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

421329

DHR13
Dehydrogenase/reductase SDR family member 13

1

0

High-throughput

0.249

Low

421330

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

421331

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

421332

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

421334

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.249

Low

421344

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

421359

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

421363

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

421293

NARR
Ras-related protein Rab-34, isoform NARR

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024