HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 975
+	Hs
		789085 ABL2_HUMAN (10-1130): 0: 775: 52.62		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		337392 ABL1_HUMAN (1-1130): 0: 984: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		337496 ABL1_HUMAN (1-1130): 0: 984: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		789045 ABL2_HUMAN (10-1130): 0: 775: 52.62		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		412307 FYN_HUMAN (18-510): 0: 543: 38.64		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		522850 SRC_HUMAN (13-510): 0: 547: 38.58		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		412081 FYN_HUMAN (18-510): 0: 543: 38.64		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		433282 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		454848 FGR_HUMAN (2-509): 5.33e-178: 533: 38.88		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		411864 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		986397 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		996573 ITK_HUMAN (44-499): 1.16e-153: 474: 34.74		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71