HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.828

Property	Details
Experiments	19891780, 11374898
Identification Methods	enzymatic study, affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9, SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 1292
+	Hs
		337470 ABL1_HUMAN (1-1130): 0: 984: 100.00		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		337337 ABL1_HUMAN (1-1130): 0: 984: 100.00		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		337296 ABL1_HUMAN (1-1130): 0: 984: 100.00		SPTA1_HUMAN (303-1028): 9.45e-45: 180: 9.89
+	Hs
		523130 SRC_HUMAN (13-510): 0: 547: 38.58		SRBS1_HUMAN (1-1292): 5.5e-176: 558: 100.00
+	Mm
		337637 ABL1_MOUSE (1-1130): 0: 901: 85.00		NCK1_MOUSE (708-1005): 1.97e-49: 182: 17.63
+	Hs
		298944 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		235462 ABL1_HUMAN (1-1130): 0: 984: 100.00		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59
+	Hs
		557630 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		209001 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Hs
		789066 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Hs
		298959 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		235483 ABL2_HUMAN (10-1130): 0: 775: 52.62		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59
+	Hs
		411715 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		433753 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		411986 FYN_HUMAN (18-510): 0: 543: 38.64		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Mm
		763403 FYN_MOUSE (18-510): 0: 542: 38.64		NCK1_MOUSE (708-1005): 1.97e-49: 182: 17.63
+	Hs
		522981 SRC_HUMAN (13-510): 0: 547: 38.58		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Hs
		433350 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Hs
		433732 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		433781 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91