Protein: ACM4
Muscarinic acetylcholine receptor M4

Gene: ACM4, CHRM4
Organism: Homo sapiens
Interactions: 166
UniProt ID: P08173

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007166 - cell surface receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 - adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

316593

ST17B
Serine/threonine-protein kinase 17B

2

2

High-throughput

0.811

High

466872

TTK
Dual specificity protein kinase TTK

2

4

High-throughput

0.726

High

466857

ACM4
Muscarinic acetylcholine receptor M4

1

16

Small-scale

0.647

High

466890

TBB3
Tubulin beta-3 chain

2

4

High-throughput

0.628

High

466909

MRP7
ATP-binding cassette sub-family C member 10

2

2

High-throughput

0.628

High

466939

EXOC6
Exocyst complex component 6

2

1

High-throughput

0.628

High

466940

CIP2A
Protein CIP2A

2

1

High-throughput

0.628

High

466973

VEZA
Vezatin

2

1

High-throughput

0.628

High

133158

QSOX1
Sulfhydryl oxidase 1

1

1

High-throughput

0.625

High

466869

5HT2C
5-hydroxytryptamine receptor 2C

1

19

Small-scale

0.618

High

466987

XPO7
Exportin-7

3

7

High-throughput

0.604

High

466878

KNTC1
Kinetochore-associated protein 1

2

0

High-throughput

0.602

High

466921

SARM1
NAD(+) hydrolase SARM1

2

0

High-throughput

0.602

High

466953

XPO6
Exportin-6

2

0

High-throughput

0.602

High

466954

S29A1
Equilibrative nucleoside transporter 1

2

0

High-throughput

0.602

High

343548

OXSR1
Serine/threonine-protein kinase OSR1

1

1

High-throughput

0.575

High

466984

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

1

High-throughput

0.575

High

273154

CAND2
Cullin-associated NEDD8-dissociated protein 2

2

6

High-throughput

0.574

High

466864

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

2

3

High-throughput

0.574

High

466885

TBA4A
Tubulin alpha-4A chain

2

3

High-throughput

0.574

High

466911

ECM29
Proteasome adapter and scaffold protein ECM29

2

8

High-throughput

0.574

High

466916

RINT1
RAD50-interacting protein 1

2

1

High-throughput

0.574

High

466917

MBOA5
Lysophospholipid acyltransferase 5

2

4

High-throughput

0.574

High

466920

BRAT1
Integrator complex assembly factor BRAT1

2

1

High-throughput

0.574

High

466923

THADA
tRNA

2

2

High-throughput

0.574

High

466924

CERS6
Ceramide synthase 6

2

14

High-throughput

0.574

High

466929

HEAT3
HEAT repeat-containing protein 3

2

2

High-throughput

0.574

High

466952

IPO9
Importin-9

2

11

High-throughput

0.574

High

466960

GCP2
Gamma-tubulin complex component 2

2

2

High-throughput

0.574

High

466969

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

2

1

High-throughput

0.574

High

466979

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

2

High-throughput

0.574

High

466986

IPO11
Importin-11

2

11

High-throughput

0.574

High

466988

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

2

High-throughput

0.574

High

466989

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

2

3

High-throughput

0.574

High

164513

TNPO2
Transportin-2

2

9

High-throughput

0.558

High

466877

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

0

High-throughput

0.546

High

466861

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

466865

RAB3A
Ras-related protein Rab-3A

1

3

High-throughput

0.541

High

466875

TSN7
Tetraspanin-7

1

14

High-throughput

0.541

High

466882

CD81
CD81 antigen

1

13

High-throughput

0.541

High

466883

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

2

High-throughput

0.541

High

466948

SYN2
Synapsin-2

1

1

High-throughput

0.541

High

466965

YIPF3
Protein YIPF3

1

5

High-throughput

0.541

High

466976

RTN4
Reticulon-4

1

5

High-throughput

0.541

High

443626

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

6

High-throughput

0.536

High

466859

ADT1
ADP/ATP translocase 1

1

5

High-throughput

0.536

High

466862

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

8

High-throughput

0.536

High

466866

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.536

High

466910

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.536

High

466926

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.536

High

466961

YIPF4
Protein YIPF4

1

3

High-throughput

0.536

High

302274

ERG24
Delta(14)-sterol reductase TM7SF2

1

0

High-throughput

0.518

High

466863

CD59
CD59 glycoprotein

1

0

High-throughput

0.518

High

466974

NEK6
Serine/threonine-protein kinase Nek6

1

1

High-throughput

0.514

High

466894

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.513

High

466930

T179B
Transmembrane protein 179B

1

0

High-throughput

0.513

High

466937

MIGA1
Mitoguardin 1

1

0

High-throughput

0.513

High

466950

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.513

High

466908

PR15B
Protein phosphatase 1 regulatory subunit 15B

2

1

High-throughput

0.504

High

466914

RHBD2
Rhomboid domain-containing protein 2

1

4

High-throughput

0.494

High

466959

SMIM7
Small integral membrane protein 7

1

1

High-throughput

0.494

High

466966

METL9
Protein-L-histidine N-pros-methyltransferase

1

1

High-throughput

0.494

High

172411

XPO1
Exportin-1

1

10

High-throughput

0.489

High

466860

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.489

High

466884

ACTA
Actin, aortic smooth muscle

1

10

High-throughput

0.489

High

466886

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.489

High

466936

ARL10
ADP-ribosylation factor-like protein 10

1

8

High-throughput

0.489

High

466941

IPO4
Importin-4

1

8

High-throughput

0.489

High

466942

COG1
Conserved oligomeric Golgi complex subunit 1

1

2

High-throughput

0.489

High

466945

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.489

High

466947

GCN1
Stalled ribosome sensor GCN1

1

3

High-throughput

0.489

High

466958

CND3
Condensin complex subunit 3

1

1

High-throughput

0.489

High

466964

XPO4
Exportin-4

1

4

High-throughput

0.489

High

466971

COG4
Conserved oligomeric Golgi complex subunit 4

1

1

High-throughput

0.489

High

466978

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

2

High-throughput

0.489

High

466985

GCP4
Gamma-tubulin complex component 4

1

2

High-throughput

0.489

High

466873

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

466955

SH3G1
Endophilin-A2

1

20

Small-scale

0.479

High

466956

SH3G2
Endophilin-A1

1

20

Small-scale

0.479

High

466957

SH3G3
Endophilin-A3

1

20

Small-scale

0.479

High

376944

NGF
Beta-nerve growth factor

1

0

Small-scale

0.458

High

164225

NRP1
Neuropilin-1

1

3

High-throughput

0.445

High

189090

IPO8
Importin-8

1

11

High-throughput

0.445

High

301304

WFS1
Wolframin

1

2

High-throughput

0.445

High

337548

FMNL1
Formin-like protein 1

1

1

High-throughput

0.445

High

462948

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.445

High

466879

STAT2
Signal transducer and activator of transcription 2

1

3

High-throughput

0.445

High

466880

EPHB4
Ephrin type-B receptor 4

1

1

High-throughput

0.445

High

466900

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.445

High

466902

QRIC1
Transcriptional regulator QRICH1

1

1

High-throughput

0.445

High

466892

SNX1
Sorting nexin-1

1

4

Small-scale

0.437

High

466907

GASP1
G-protein coupled receptor-associated sorting protein 1

1

12

Small-scale

0.437

High

466881

GSDMD
Gasdermin-D

1

0

High-throughput

0.426

High

466891

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.426

High

466938

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.426

High

466967

EHD4
EH domain-containing protein 4

1

0

High-throughput

0.426

High

466968

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

466975

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.426

High

159473

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

12

High-throughput

0.407

High

229399

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

4

High-throughput

0.407

High

255364

SNX2
Sorting nexin-2

1

4

High-throughput

0.407

High

255738

USO1
General vesicular transport factor p115

1

3

High-throughput

0.407

High

291189

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.407

High

329206

LETM1
Mitochondrial proton/calcium exchanger protein

1

1

High-throughput

0.407

High

466858

PYC
Pyruvate carboxylase, mitochondrial

1

1

High-throughput

0.407

High

466867

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.407

High

466893

UBE4A
Ubiquitin conjugation factor E4 A

1

1

High-throughput

0.407

High

466898

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.407

High

466899

INF2
Inverted formin-2

1

1

High-throughput

0.407

High

466901

ERC6L
DNA excision repair protein ERCC-6-like

1

2

High-throughput

0.407

High

466903

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

4

High-throughput

0.407

High

466904

Q4LE60
TNPO2 variant protein

1

9

High-throughput

0.407

High

466915

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

5

High-throughput

0.407

High

466925

TMTC3
Protein O-mannosyl-transferase TMTC3

1

1

High-throughput

0.407

High

466928

CLAP1
CLIP-associating protein 1

1

2

High-throughput

0.407

High

466934

ARM10
Armadillo repeat-containing protein 10

1

12

High-throughput

0.407

High

466943

DCAKD
Dephospho-CoA kinase domain-containing protein

1

1

High-throughput

0.407

High

466944

SYNE2
Nesprin-2

1

5

High-throughput

0.407

High

466949

RAD50
DNA repair protein RAD50

1

3

High-throughput

0.407

High

466972

PKHA5
Pleckstrin homology domain-containing family A member 5

1

3

High-throughput

0.407

High

466977

SAR1A
Small COPII coat GTPase SAR1A

1

3

High-throughput

0.407

High

466983

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.407

High

466991

EXC6B
Exocyst complex component 6B

1

1

High-throughput

0.407

High

167049

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.328

High

187446

FANCA
Fanconi anemia group A protein

2

0

High-throughput

0.328

High

211719

ZW10
Centromere/kinetochore protein zw10 homolog

2

0

High-throughput

0.328

High

466871

GLPK
Glycerol kinase

2

0

High-throughput

0.328

High

466896

COG2
Conserved oligomeric Golgi complex subunit 2

2

0

High-throughput

0.328

High

466912

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

0

High-throughput

0.328

High

466913

F91A1
Protein FAM91A1

2

0

High-throughput

0.328

High

466918

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

2

0

High-throughput

0.328

High

466919

INT5
Integrator complex subunit 5

2

0

High-throughput

0.328

High

466933

DAAF5
Dynein axonemal assembly factor 5

2

0

High-throughput

0.328

High

270227

MTG16
Protein CBFA2T3

1

0

High-throughput

0.282

High

466888

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

High-throughput

0.282

High

466935

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.282

High

466990

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.282

High

466931

ADCK1
AarF domain-containing protein kinase 1

1

0

High-throughput

0.279

Low

466962

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.279

Low

137173

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.232

Low

177511

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.232

Low

301838

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.232

Low

350343

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

High-throughput

0.232

Low

359784

DYR
Dihydrofolate reductase

1

0

High-throughput

0.232

Low

466868

KTHY
Thymidylate kinase

1

0

High-throughput

0.232

Low

466870

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

466874

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.232

Low

466876

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.232

Low

466887

MMSA
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

1

0

High-throughput

0.232

Low

466889

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

466895

PUM1
Pumilio homolog 1

1

0

High-throughput

0.232

Low

466897

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.232

Low

466905

HIKES
Protein Hikeshi

1

0

High-throughput

0.232

Low

466906

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

466922

TMT1B
Thiol S-methyltransferase TMT1B

1

0

High-throughput

0.232

Low

466927

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.232

Low

466932

AACS
Acetoacetyl-CoA synthetase

1

0

High-throughput

0.232

Low

466946

TBCD5
TBC1 domain family member 5

1

0

High-throughput

0.232

Low

466951

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.232

Low

466963

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.232

Low

466970

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.232

Low

466980

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

466981

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.232

Low

466982

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.232

Low

466992

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025