HitPredict

Interactor 1: ABL1 (P00520)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	20697350, 10823839, 15148308
Identification Methods	affinity chromatography technology, kinase homogeneous time resolved fluorescence, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1123 Mm			1 482
+	Hs
		337542 ABL1_HUMAN (1-1123): 0: 925: 85.88		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Mm
		337639 ABL1_MOUSE (1-1123): 0: 973: 100.00		DOK3_MOUSE (1-460): 1.73e-119: 359: 30.30
+	Hs
		789086 ABL2_HUMAN (11-1123): 0: 775: 50.90		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Mm
		250948 ABL1_MOUSE (1-1123): 0: 973: 100.00		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Hs
		235031 ABL1_HUMAN (1-1123): 0: 925: 85.88		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		433460 YES_HUMAN (5-510): 0: 542: 39.42		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		523124 SRC_HUMAN (36-510): 0: 541: 39.96		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		996570 ITK_HUMAN (44-499): 4.44e-175: 529: 35.50		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		442876 HCK_HUMAN (9-508): 1.52e-173: 522: 38.60		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		235037 YES_HUMAN (5-510): 0: 542: 39.42		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		235040 SRC_HUMAN (36-510): 0: 541: 39.96		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		235036 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Mm
		250949 SRC_MOUSE (32-510): 1.48e-179: 537: 39.84		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Hs
		235035 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		151689 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		IRS4_HUMAN (6-406): 7.52e-92: 305: 14.29
+	Mm
		403453 SRC_MOUSE (32-510): 1.48e-179: 537: 39.84		FRS2_MOUSE (135-478): 4.6e-72: 238: 19.54
+	Hs
		411805 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		FRS2_HUMAN (135-478): 2.91e-75: 247: 20.31
+	Hs
		412057 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		IRS1_HUMAN (6-360): 6.38e-68: 237: 16.01
+	Hs
		207290 HCK_HUMAN (9-508): 1.52e-173: 522: 38.60		FRS3_HUMAN (135-480): 5.71e-67: 224: 19.11
+	Dm
		1360394 SRC42_DROME (10-508): 4.13e-174: 523: 39.22		Q9W3R6_DROME (1-257): 3.27e-59: 207: 25.38