Protein: FMNL2
Formin-like protein 2 (Formin homology 2 domain-containing protein 2)

Gene: FMNL2
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q96PY5

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0007010 - cytoskeleton organization
GO:0008360 - regulation of cell shape
GO:0016477 - cell migration
GO:0022604 - regulation of cell morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955491

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.793

High

466419

RHOC
Rho-related GTP-binding protein RhoC

2

20

High-throughput

0.754

High

956449

RAB2A
Ras-related protein Rab-2A

2

10

High-throughput

0.754

High

978231

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

993299

ACTG
Actin, cytoplasmic 2

1

15

High-throughput

0.691

High

1308691

FMNL3
Formin-like protein 3

1

11

High-throughput

0.691

High

1105161

U119A
Protein unc-119 homolog A

2

1

High-throughput

0.628

High

126749

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

337607

FMNL1
Formin-like protein 1

1

11

High-throughput

0.618

High

374860

RASH
GTPase HRas

1

12

High-throughput

0.618

High

375850

RASK
GTPase KRas

1

19

High-throughput

0.618

High

955992

RAB8A
Ras-related protein Rab-8A

1

5

High-throughput

0.618

High

962396

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

988622

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1145064

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

1400324

FMNL2
Formin-like protein 2

1

11

High-throughput

0.618

High

1400340

RAB6B
Ras-related protein Rab-6B

1

9

High-throughput

0.618

High

1400115

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

2

High-throughput

0.601

High

1400328

THIOM
Thioredoxin, mitochondrial

2

1

High-throughput

0.560

High

923627

TTC3
E3 ubiquitin-protein ligase TTC3

1

2

High-throughput

0.541

High

457903

INVO
Involucrin

1

2

High-throughput

0.536

High

459723

PROF1
Profilin-1

1

11

High-throughput

0.536

High

874846

SPB4
Serpin B4

1

3

High-throughput

0.536

High

1030678

ANK2
Ankyrin-2

1

2

High-throughput

0.536

High

1286347

S1A7A
Protein S100-A7A

1

3

High-throughput

0.536

High

1289099

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

High-throughput

0.536

High

1358554

POF1B
Protein POF1B

1

1

High-throughput

0.536

High

1336451

PNMA1
Paraneoplastic antigen Ma1

2

1

High-throughput

0.533

High

873993

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

254210

CTND1
Catenin delta-1

1

3

High-throughput

0.515

High

764412

CTNA1
Catenin alpha-1

1

2

High-throughput

0.515

High

1124691

SRC8
Src substrate cortactin

1

2

High-throughput

0.515

High

1163150

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.515

High

1270502

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.515

High

1400343

RAI14
Ankycorbin

1

6

High-throughput

0.515

High

1400356

MRCKB
Serine/threonine-protein kinase MRCK beta

1

3

High-throughput

0.515

High

321116

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.513

High

280787

PR40A
Pre-mRNA-processing factor 40 homolog A

1

16

High-throughput

0.508

High

422939

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

369493

AACT
Alpha-1-antichymotrypsin

1

3

High-throughput

0.489

High

915908

CRIP2
Cysteine-rich protein 2

1

2

High-throughput

0.489

High

1009702

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.489

High

1359073

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.489

High

1384110

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

989085

AP2B1
AP-2 complex subunit beta

1

6

High-throughput

0.481

High

1083297

AP1B1
AP-1 complex subunit beta-1

1

4

High-throughput

0.481

High

1277611

K1C27
Keratin, type I cytoskeletal 27

1

1

High-throughput

0.481

High

1331723

NECA1
N-terminal EF-hand calcium-binding protein 1

1

1

High-throughput

0.481

High

143684

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

217507

E41L2
Band 4.1-like protein 2

1

6

High-throughput

0.479

High

242640

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

255473

SNX2
Sorting nexin-2

1

3

High-throughput

0.479

High

269599

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

5

High-throughput

0.479

High

343449

SNP29
Synaptosomal-associated protein 29

1

1

High-throughput

0.479

High

401328

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.479

High

431880

ITB1
Integrin beta-1

1

3

High-throughput

0.479

High

463712

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

538999

EPB41
Protein 4.1

1

5

High-throughput

0.479

High

556292

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

568277

PLST
Plastin-3

1

2

High-throughput

0.479

High

577863

PLAK
Junction plakoglobin

1

3

High-throughput

0.479

High

599619

STMN1
Stathmin

1

1

High-throughput

0.479

High

692120

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.479

High

762037

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

764976

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

774102

ADDA
Alpha-adducin

1

2

High-throughput

0.479

High

889327

NUMB
Protein numb homolog

1

1

High-throughput

0.479

High

936416

AFAD
Afadin

1

7

High-throughput

0.479

High

975185

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

989374

VAMP2
Vesicle-associated membrane protein 2

1

3

High-throughput

0.479

High

1039983

AKA12
A-kinase anchor protein 12

1

1

High-throughput

0.479

High

1052089

CALD1
Caldesmon

1

11

High-throughput

0.479

High

1106499

GAB1
GRB2-associated-binding protein 1

1

2

High-throughput

0.479

High

1111963

SNX1
Sorting nexin-1

1

3

High-throughput

0.479

High

1119874

CKAP5
Cytoskeleton-associated protein 5

1

1

High-throughput

0.479

High

1122316

SCRIB
Protein scribble homolog

1

1

High-throughput

0.479

High

1137000

SEPT2
Septin-2

1

2

High-throughput

0.479

High

1146333

L2GL1
Lethal(2) giant larvae protein homolog 1

1

1

High-throughput

0.479

High

1154716

VAMP3
Vesicle-associated membrane protein 3

1

2

High-throughput

0.479

High

1156409

SEPT7
Septin-7

1

2

High-throughput

0.479

High

1191467

GRDN
Girdin

1

7

High-throughput

0.479

High

1217554

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

2

High-throughput

0.479

High

1220749

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1275619

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

6

High-throughput

0.479

High

1278271

NPHP3
Nephrocystin-3

1

3

High-throughput

0.479

High

1292188

LIPB1
Liprin-beta-1

1

6

High-throughput

0.479

High

1331352

ENAH
Protein enabled homolog

1

9

High-throughput

0.479

High

1349682

CIP2A
Protein CIP2A

1

3

High-throughput

0.479

High

1366023

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

3

High-throughput

0.479

High

1366771

NECT2
Nectin-2

1

2

High-throughput

0.479

High

1369593

NEO1
Neogenin

1

1

High-throughput

0.479

High

1371922

STMN2
Stathmin-2

1

1

High-throughput

0.479

High

1380097

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1398821

DOCK7
Dedicator of cytokinesis protein 7

1

1

High-throughput

0.479

High

1400325

RUFY1
RUN and FYVE domain-containing protein 1

1

8

High-throughput

0.479

High

1400326

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

High-throughput

0.479

High

1400329

SH3G1
Endophilin-A2

1

4

High-throughput

0.479

High

1400334

PKHA1
Pleckstrin homology domain-containing family A member 1

1

2

High-throughput

0.479

High

1400335

E41L5
Band 4.1-like protein 5

1

5

High-throughput

0.479

High

1400336

WDR6
tRNA

1

3

High-throughput

0.479

High

1400337

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

1400341

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.479

High

1400344

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

5

High-throughput

0.479

High

1400345

ADDG
Gamma-adducin

1

2

High-throughput

0.479

High

1400346

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1400347

SEPT9
Septin-9

1

2

High-throughput

0.479

High

1400348

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

5

High-throughput

0.479

High

1400349

DBNL
Drebrin-like protein

1

3

High-throughput

0.479

High

1400350

KDIS
Kinase D-interacting substrate of 220 kDa

1

2

High-throughput

0.479

High

1400351

BAIP2
BAR/IMD domain-containing adapter protein 2

1

3

High-throughput

0.479

High

1400352

CHM2B
Charged multivesicular body protein 2b

1

1

High-throughput

0.479

High

1400354

E41L3
Band 4.1-like protein 3

1

6

High-throughput

0.479

High

1400355

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.479

High

1400357

SNX9
Sorting nexin-9

1

5

High-throughput

0.479

High

1400358

SNX5
Sorting nexin-5

1

3

High-throughput

0.479

High

1400359

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.479

High

1400361

ROBO1
Roundabout homolog 1

1

1

High-throughput

0.479

High

192299

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

467583

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

878341

MRP
MARCKS-related protein

1

0

High-throughput

0.458

High

897367

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

1024776

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1091560

DLG1
Disks large homolog 1

1

0

High-throughput

0.458

High

1107599

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.458

High

1129859

EPN4
Clathrin interactor 1

1

0

High-throughput

0.458

High

1195308

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.458

High

1204786

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

0

High-throughput

0.458

High

1356361

ZC3HF
Zinc finger CCCH domain-containing protein 15

1

0

High-throughput

0.458

High

1365171

NDRG1
Protein NDRG1

1

0

High-throughput

0.458

High

1382768

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.458

High

1400327

NIBA2
Protein Niban 2

1

0

High-throughput

0.458

High

1400333

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.458

High

1056915

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

591350

CD44
CD44 antigen

1

1

High-throughput

0.445

High

809794

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.445

High

1234913

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

907182

SUOX
Sulfite oxidase, mitochondrial

1

2

High-throughput

0.439

High

1350348

MIPO1
Mirror-image polydactyly gene 1 protein

1

1

High-throughput

0.439

High

533741

CLUS
Clusterin

1

0

High-throughput

0.438

High

1400339

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

75709

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

106499

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

124092

SNP23
Synaptosomal-associated protein 23

1

1

High-throughput

0.437

High

248048

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

299338

FLOT1
Flotillin-1

1

3

High-throughput

0.437

High

302931

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.437

High

348188

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

3

High-throughput

0.437

High

372891

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

412460

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

548582

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.437

High

755509

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.437

High

783167

ARL3
ADP-ribosylation factor-like protein 3

1

7

High-throughput

0.437

High

845763

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.437

High

1004167

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.437

High

1047706

NOTC2
Neurogenic locus notch homolog protein 2

1

1

High-throughput

0.437

High

1090174

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

6

High-throughput

0.437

High

1120799

DSG2
Desmoglein-2

1

4

High-throughput

0.437

High

1141271

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.437

High

1191941

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.437

High

1233428

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.437

High

1255134

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1275447

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

3

High-throughput

0.437

High

1316515

UNC5B
Netrin receptor UNC5B

1

1

High-throughput

0.437

High

1322953

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1400331

SIK2
Serine/threonine-protein kinase SIK2

1

2

Small-scale

0.437

High

1400338

NECT3
Nectin-3

1

2

High-throughput

0.437

High

1400353

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.437

High

69533

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

1146610

TMED2
Transmembrane emp24 domain-containing protein 2

1

1

High-throughput

0.407

High

1147662

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

High-throughput

0.407

High

1326040

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

1397954

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.407

High

938179

PKNX1
Homeobox protein PKNOX1

1

0

High-throughput

0.282

High

1395272

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

690537

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.279

Low

1338061

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.279

Low

1315893

PHAR4
Phosphatase and actin regulator 4

1

0

High-throughput

0.269

Low

1198506

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.249

Low

1278392

HDDC2
5'-deoxynucleotidase HDDC2

1

0

High-throughput

0.249

Low

1280150

ARPIN
Arpin

1

0

High-throughput

0.249

Low

1293285

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.249

Low

1337050

CNNM3
Metal transporter CNNM3

1

0

High-throughput

0.249

Low

1400330

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

1400332

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.249

Low

1400342

HACD3
Very-long-chain

1

0

High-throughput

0.249

Low

1400360

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025