Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 24797263, 8870675, 12297049, 12297050, 12620237, 25453753, 2732223, 23794705, 21775422, 23595626, 20456371, 28065597, 24135280, 24077285, 11087732, 6321473, 2915986, 19560417, 9092812, 9815748 and 33 others

more...

Identification Methods affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfer, protein complementation assay, biochemical, two hybrid, beta galactosidase complementation, anti tag coimmunoprecipitation and 9 others

more...

Interaction Type physical association, direct interaction, association, phosphotransfer reaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain
Common GO terms GO:0000139 - Golgi membrane
GO:0001503 - ossification
GO:0001618 - virus receptor activity
GO:0001892 - embryonic placenta development
GO:0001934 - positive regulation of protein phosphorylation
and 126 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 1210
+ Mm
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024