Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.99 | 1.00 | 0.996 |
The method score is based on:
Property | Details |
---|---|
Experiments | 24797263, 8870675, 12297049, 12297050, 12620237, 25453753, 2732223, 23794705, 21775422, 23595626, 20456371, 28065597, 24135280, 24077285, 11087732, 6321473, 2915986, 19560417, 9092812, 9815748 and 33 others
more... |
Identification Methods | affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfer, protein complementation assay, biochemical, two hybrid, beta galactosidase complementation, anti tag coimmunoprecipitation and 9 others
more... |
Interaction Type | physical association, direct interaction, association, phosphotransfer reaction, phosphorylation reaction |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain |
Common GO terms | GO:0000139 - Golgi membrane GO:0001503 - ossification GO:0001618 - virus receptor activity GO:0001892 - embryonic placenta development GO:0001934 - positive regulation of protein phosphorylation and 126 others more... |
Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024