HitPredict

Interactor 1: LYOX (P28300)
Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]
Gene: LOX

Interactor 2: FBN1 (P35555)
Fibrillin-1 [Cleaved into: Asprosin]
Gene: FBN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	19570982, 19755719
Identification Methods	enzyme linked immunosorbent assay, pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0007507 - heart development GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 2871
+	Hs
		724338 LOXL1_HUMAN (125-414): 7.23e-142: 418: 60.27		FBN1_HUMAN (1-2871): 0: 1360: 100.00
+	Hs
		657674 LYOX_HUMAN (1-417): 0: 746: 100.00		LTBP1_HUMAN (1-654): 8.92e-20: 100: 16.85
+	Hs
		82344 B9A025_HUMAN (197-414): 4.65e-127: 380: 49.32		LTBP1_HUMAN (1-654): 8.92e-20: 100: 16.85
+	Hs
		885372 LOXL3_HUMAN (197-414): 4.66e-124: 378: 49.32		LTBP1_HUMAN (1-654): 8.92e-20: 100: 16.85
+	Mm
		957044 LOXL1_MOUSE (149-414): 1.96e-134: 400: 61.87		FBLN5_MOUSE (1606-1875): 3.26e-09: 63.9: 26.65
+	Dm
		422950 Q9W2C9_DROME (210-414): 4.87e-111: 337: 40.95		NOTCH_DROME (2448-2818): 1.83e-22: 108: 17.91