HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: FES (P07332)
Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
Gene: FES

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0018108 - peptidyl-tyrosine phosphorylation and 1 others more... GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 822
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (1-820): 0: 874: 50.30
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (368-817): 2.56e-160: 499: 32.70
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (399-816): 3.46e-159: 475: 31.83
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (323-816): 1.35e-152: 458: 30.44
+	Hs
		338144 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLK_HUMAN (365-818): 4.82e-159: 474: 30.72
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (335-817): 1.75e-156: 468: 29.16
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (325-821): 7.35e-154: 465: 28.17
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (399-816): 2.3e-154: 464: 33.41
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (376-816): 5.61e-153: 460: 32.98
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (382-817): 1.65e-152: 457: 31.82
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (368-817): 1.6e-152: 457: 30.80
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (357-816): 1.9e-151: 455: 28.83
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (322-820): 3.86e-147: 447: 30.62
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (323-816): 2.27e-147: 445: 30.62
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (401-821): 2.97e-146: 439: 33.26
+	Hs
		337480 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35
+	Hs
		338080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MATK_HUMAN (436-814): 3.24e-68: 236: 39.44
+	Hs
		338158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BMX_HUMAN (460-822): 1.77e-66: 236: 36.98
+	Hs
		338082 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXK_HUMAN (460-817): 1.3e-65: 229: 36.51