HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CXB1 (P08034)
Gap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDa liver protein)
Gene: GJB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30401746
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 283
+	Hs
		337893 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		338688 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CXD3_HUMAN (2-223): 1.1e-90: 272: 38.74
+	Hs
		567066 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		383593 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		434822 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		CXB1_HUMAN (1-283): 6.23e-161: 450: 100.00
+	Hs
		566985 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		566935 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		411289 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		566936 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45
+	Hs
		665269 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		CXB7_HUMAN (1-216): 7.19e-100: 293: 48.15
+	Hs
		1072544 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		CXD3_HUMAN (2-223): 1.1e-90: 272: 38.74
+	Hs
		665282 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		CXD3_HUMAN (2-223): 1.1e-90: 272: 38.74
+	Hs
		411435 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		CXD3_HUMAN (2-223): 1.1e-90: 272: 38.74
+	Hs
		435527 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		CXA1_HUMAN (2-227): 2.73e-108: 320: 42.45