Protein: SGPL1
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)

Gene: SGPL1
Organism: Homo sapiens
Interactions: 223
UniProt ID: O95470

Gene Ontology (top 5):
GO:0001553 - luteinization
GO:0001570 - vasculogenesis
GO:0001822 - kidney development
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337758

BT2A1
Butyrophilin subfamily 2 member A1

3

2

High-throughput

0.770

High

337845

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

0

High-throughput

0.720

High

337766

TARG1
Trafficking regulator of GLUT4 1

4

1

High-throughput

0.634

High

337666

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

337784

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

1

High-throughput

0.628

High

337655

SGPL1
Sphingosine-1-phosphate lyase 1

1

17

High-throughput

0.618

High

337660

EGFR
Epidermal growth factor receptor

2

1

High-throughput

0.611

High

337721

PLP2
Proteolipid protein 2

2

3

High-throughput

0.606

High

337759

FA2H
Fatty acid 2-hydroxylase

2

1

High-throughput

0.606

High

337834

CCG5
Voltage-dependent calcium channel gamma-5 subunit

3

2

High-throughput

0.604

High

337755

ANR12
Ankyrin repeat domain-containing protein 12

3

3

High-throughput

0.599

High

337764

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.586

High

240379

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

337688

HMOX2
Heme oxygenase 2

2

0

High-throughput

0.580

High

337732

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.580

High

337741

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

337787

B2CL2
Bcl-2-like protein 2

2

0

High-throughput

0.580

High

337829

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

High-throughput

0.580

High

337838

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

337842

STX8
Syntaxin-8

2

0

High-throughput

0.580

High

276232

SEM7A
Semaphorin-7A

2

2

High-throughput

0.574

High

337657

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

3

High-throughput

0.574

High

337691

CADH5
Cadherin-5

2

2

High-throughput

0.574

High

337809

TRIM9
E3 ubiquitin-protein ligase TRIM9

2

6

High-throughput

0.574

High

337712

RHOA
Transforming protein RhoA

2

1

High-throughput

0.571

High

165161

TSN4
Tetraspanin-4

2

1

High-throughput

0.553

High

213671

AQP9
Aquaporin-9

2

2

High-throughput

0.553

High

337756

MFSD6
Major facilitator superfamily domain-containing protein 6

2

1

High-throughput

0.553

High

337779

SCAM5
Secretory carrier-associated membrane protein 5

2

1

High-throughput

0.553

High

337785

AQP3
Aquaporin-3

2

1

High-throughput

0.553

High

337762

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

2

1

High-throughput

0.549

High

337763

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

2

1

High-throughput

0.549

High

208939

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.536

High

337680

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

337684

CALX
Calnexin

1

1

High-throughput

0.536

High

337695

APJ
Apelin receptor

1

1

High-throughput

0.536

High

337696

BASI
Basigin

1

1

High-throughput

0.536

High

337791

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.536

High

337815

CSTN2
Calsyntenin-2

1

3

High-throughput

0.536

High

337820

CHODL
Chondrolectin

1

2

High-throughput

0.536

High

337851

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

337725

PTK6
Protein-tyrosine kinase 6

2

5

High-throughput

0.521

High

337698

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.517

High

337659

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.513

High

337673

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

337682

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

337728

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

337742

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

337748

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.513

High

337790

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

337802

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

0

High-throughput

0.513

High

337805

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

337812

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

125119

LEG9
Galectin-9

1

1

High-throughput

0.489

High

164889

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.489

High

182445

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.489

High

337663

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

337674

CADH1
Cadherin-1

1

4

High-throughput

0.489

High

337676

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.489

High

337711

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

337713

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.489

High

337719

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.489

High

337723

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.489

High

337729

RBM39
RNA-binding protein 39

1

3

High-throughput

0.489

High

337734

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

337736

PKN2
Serine/threonine-protein kinase N2

1

4

High-throughput

0.489

High

337737

DDB1
DNA damage-binding protein 1

1

2

High-throughput

0.489

High

337792

ARRD3
Arrestin domain-containing protein 3

1

1

High-throughput

0.489

High

337798

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.489

High

337840

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.489

High

337848

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

337849

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

164206

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

173813

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

337669

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

337675

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

337683

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

337697

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

337761

CNTRL
Centriolin

1

3

High-throughput

0.479

High

337776

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

337804

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

337807

DERL1
Derlin-1

1

2

High-throughput

0.479

High

63630

A5PKU2
TUSC5 protein

1

1

High-throughput

0.470

High

337661

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

337710

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

337800

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

337821

LFG4
Protein lifeguard 4

1

0

High-throughput

0.458

High

337718

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.457

High

337739

DDR2
Discoidin domain-containing receptor 2

1

7

High-throughput

0.457

High

208447

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

High-throughput

0.445

High

337708

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.445

High

337808

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.445

High

337811

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.445

High

337816

OSBL3
Oxysterol-binding protein-related protein 3

1

1

High-throughput

0.445

High

128696

MEN1
Menin

1

1

High-throughput

0.437

High

159446

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.437

High

169871

AURKA
Aurora kinase A

1

5

High-throughput

0.437

High

337656

ERR2
Steroid hormone receptor ERR2

1

4

High-throughput

0.437

High

337662

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

337664

HBD
Hemoglobin subunit delta

1

1

High-throughput

0.437

High

337672

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

337677

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

337700

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

337706

ATX1
Ataxin-1

1

1

High-throughput

0.437

High

337751

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

337752

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

337757

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

337768

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

337786

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

337793

OTUL
Ubiquitin thioesterase otulin

1

1

Small-scale

0.437

High

337797

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

337810

BRD8
Bromodomain-containing protein 8

1

3

High-throughput

0.437

High

337817

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

337823

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.437

High

337827

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

337831

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

337835

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

337841

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.437

High

294641

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

337745

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

104082

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

283639

GPC4
Glypican-4

1

2

High-throughput

0.407

High

337668

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.407

High

337670

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

337679

SDC1
Syndecan-1

1

2

High-throughput

0.407

High

337681

SC6A2
Sodium-dependent noradrenaline transporter

1

1

High-throughput

0.407

High

337689

SDC4
Syndecan-4

1

2

High-throughput

0.407

High

337692

SDC2
Syndecan-2

1

2

High-throughput

0.407

High

337693

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

2

High-throughput

0.407

High

337699

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.407

High

337716

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.407

High

337735

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

1

High-throughput

0.407

High

337749

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.407

High

337753

Q6PG48
ANKRD12 protein

1

1

High-throughput

0.407

High

337794

TRI44
Tripartite motif-containing protein 44

1

1

High-throughput

0.407

High

337825

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.407

High

337844

DICER
Endoribonuclease Dicer

1

1

High-throughput

0.407

High

337850

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

2

High-throughput

0.407

High

154786

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

337818

PACC1
Proton-activated chloride channel

3

0

High-throughput

0.345

High

337704

P2RX1
P2X purinoceptor 1

2

0

High-throughput

0.328

High

337724

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.328

High

337730

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

337665

STAT
Statherin

2

0

High-throughput

0.316

High

337687

MIP
Lens fiber major intrinsic protein

2

0

High-throughput

0.316

High

337705

EFNA5
Ephrin-A5

2

0

High-throughput

0.316

High

337720

IFM3
Interferon-induced transmembrane protein 3

2

0

High-throughput

0.316

High

337722

STX4
Syntaxin-4

2

0

High-throughput

0.316

High

337740

UNC50
Protein unc-50 homolog

2

0

High-throughput

0.316

High

337743

RNS10
Inactive ribonuclease-like protein 10

2

0

High-throughput

0.316

High

337744

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

337750

PLPP4
Phospholipid phosphatase 4

2

0

High-throughput

0.316

High

337754

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.316

High

337769

PAQRA
Monocyte to macrophage differentiation factor 2

2

0

High-throughput

0.316

High

337770

F177A
Protein FAM177A1

2

0

High-throughput

0.316

High

337775

CLD19
Claudin-19

2

0

High-throughput

0.316

High

337778

CC4L
C-C motif chemokine 4-like

2

0

High-throughput

0.316

High

337799

T176A
Transmembrane protein 176A

2

0

High-throughput

0.316

High

337806

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

0

High-throughput

0.316

High

337828

TM242
Transmembrane protein 242

2

0

High-throughput

0.316

High

337830

PAQR5
Membrane progestin receptor gamma

2

0

High-throughput

0.316

High

337685

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

337788

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.298

High

186971

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.279

Low

260820

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

337667

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.279

Low

337671

NPM
Nucleophosmin

1

0

High-throughput

0.279

Low

337686

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

337690

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

337701

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

337707

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

337733

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.279

Low

337747

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

337760

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

337765

INLR1
Interferon lambda receptor 1

1

0

High-throughput

0.279

Low

337771

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

337777

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

337780

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.279

Low

337782

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

337783

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

337795

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

337796

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

337803

OPALI
Opalin

1

0

High-throughput

0.279

Low

337814

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

337833

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

337836

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

337837

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

337839

NP1L2
Nucleosome assembly protein 1-like 2

1

0

High-throughput

0.279

Low

337843

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.279

Low

337846

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

337847

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

337731

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.269

Low

131644

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.249

Low

217663

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

292984

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

337694

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

337703

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

337709

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.249

Low

337714

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

337715

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.249

Low

337717

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

337738

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

337767

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

337774

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

337781

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

337789

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.249

Low

337801

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.249

Low

337824

ANLN
Anillin

1

0

High-throughput

0.249

Low

337826

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

337832

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

132902

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.232

Low

337658

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.232

Low

337678

CD44
CD44 antigen

1

0

High-throughput

0.232

Low

337702

SL9A3
Sodium/hydrogen exchanger 3

1

0

High-throughput

0.232

Low

337726

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

337727

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.232

Low

337746

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.232

Low

337772

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

337773

CTL3
Choline transporter-like protein 3

1

0

High-throughput

0.232

Low

337813

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.232

Low

337819

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

0

High-throughput

0.232

Low

337822

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025