HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.773

The method score is based on:

Property Details
Experiments 10428778, 27059931, 28791635, 28541302, 25005938, 31120930, 31182136, 32904620, 33323455, 33627783, 33617900, 34831026, 34609770, 36543142, 20124286, 20877636, 22203672, 20940296, 14627991, 11239464 and 94 others

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Identification Methods enzymatic study, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, proximity labelling technology, protein complementation assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation and 2 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007165 - signal transduction
GO:0042059 - negative regulation of epidermal growth factor receptor signaling pathway
GO:0043066 - negative regulation of apoptotic process
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

1 906
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024