Protein: NOS2
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)

Gene: NOS2
Organism: Homo sapiens
Interactions: 171
UniProt ID: P35228

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001912 - positive regulation of leukocyte mediated cytotoxicity
GO:0002227 - innate immune response in mucosa
GO:0004517 - nitric-oxide synthase activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

766135

NOS2
Nitric oxide synthase, inducible

7

9

Small-scale

0.952

High

766222

SPSB2
SPRY domain-containing SOCS box protein 2

6

7

Small-scale

0.741

High

713152

NOS1
Nitric oxide synthase 1

1

9

High-throughput

0.691

High

766216

SPSB1
SPRY domain-containing SOCS box protein 1

4

7

Small-scale

0.680

High

766141

STAT1
Signal transducer and activator of transcription 1-alpha/beta

3

3

Small-scale

0.640

High

766186

TF65
Transcription factor p65

3

3

Small-scale

0.640

High

162795

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

2

6

Small-scale

0.600

High

766215

SPSB4
SPRY domain-containing SOCS box protein 4

2

7

Small-scale

0.595

High

370585

FOS
Protein c-Fos

2

3

Small-scale

0.584

High

429397

JUN
Transcription factor Jun

2

3

Small-scale

0.584

High

461205

HS90A
Heat shock protein HSP 90-alpha

2

5

Small-scale

0.584

High

766214

CUL5
Cullin-5

2

1

Small-scale

0.584

High

766234

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

0

Small-scale

0.576

High

580898

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

Small-scale

0.561

High

766193

RCN2
Reticulocalbin-2

1

3

High-throughput

0.553

High

766200

RCN1
Reticulocalbin-1

1

2

High-throughput

0.553

High

362866

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.534

High

766140

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.534

High

766176

RAC1
Ras-related C3 botulinum toxin substrate 1

1

10

Small-scale

0.501

High

766184

CAV1
Caveolin-1

1

4

Small-scale

0.501

High

424152

S10A8
Protein S100-A8

1

1

Small-scale

0.484

High

444920

S10A9
Protein S100-A9

1

1

Small-scale

0.484

High

408700

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.479

High

127893

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.479

High

128162

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

High-throughput

0.479

High

137987

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

141341

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

143572

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

162165

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.479

High

165273

PSA7
Proteasome subunit alpha type-7

1

4

High-throughput

0.479

High

210874

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.479

High

238657

AK1BA
Aldo-keto reductase family 1 member B10

1

2

High-throughput

0.479

High

258783

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

278251

NCOR1
Nuclear receptor corepressor 1

1

2

Small-scale

0.479

High

287874

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.479

High

348389

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

415385

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.479

High

436812

K1C18
Keratin, type I cytoskeletal 18

1

2

High-throughput

0.479

High

437106

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

468123

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

504712

FBSP1
F-box/SPRY domain-containing protein 1

1

7

High-throughput

0.479

High

532403

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

534707

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

559239

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

584070

FOSL2
Fos-related antigen 2

1

1

Small-scale

0.479

High

598017

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

4

High-throughput

0.479

High

600753

HSP76
Heat shock 70 kDa protein 6

1

1

High-throughput

0.479

High

605053

JUND
Transcription factor JunD

1

3

Small-scale

0.479

High

610244

PRS6A
26S proteasome regulatory subunit 6A

1

8

High-throughput

0.479

High

610546

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.479

High

623145

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

625770

RXRA
Retinoic acid receptor RXR-alpha

1

3

Small-scale

0.479

High

657997

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

680788

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.479

High

681112

PSA2
Proteasome subunit alpha type-2

1

5

High-throughput

0.479

High

681272

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.479

High

681580

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.479

High

687335

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.479

High

690776

1433T
14-3-3 protein theta

1

4

High-throughput

0.479

High

700563

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

717699

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.479

High

727696

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

731009

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

761554

HSP74
Heat shock 70 kDa protein 4

1

5

High-throughput

0.479

High

766136

PRS7
26S proteasome regulatory subunit 7

1

3

High-throughput

0.479

High

766137

PPARG
Peroxisome proliferator-activated receptor gamma

1

4

Small-scale

0.479

High

766138

HSPA9
Stress-70 protein, mitochondrial

1

4

High-throughput

0.479

High

766139

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.479

High

766142

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.479

High

766143

PRS6B
26S proteasome regulatory subunit 6B

1

4

High-throughput

0.479

High

766145

PA24A
Cytosolic phospholipase A2

1

2

Small-scale

0.479

High

766147

TCPE
T-complex protein 1 subunit epsilon

1

5

High-throughput

0.479

High

766148

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

766149

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.479

High

766150

EMD
Emerin

1

1

High-throughput

0.479

High

766152

TCPQ
T-complex protein 1 subunit theta

1

6

High-throughput

0.479

High

766153

TCPD
T-complex protein 1 subunit delta

1

4

High-throughput

0.479

High

766156

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

1

High-throughput

0.479

High

766159

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.479

High

766160

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.479

High

766161

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

766163

PSA6
Proteasome subunit alpha type-6

1

5

High-throughput

0.479

High

766166

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

766167

PRS4
26S proteasome regulatory subunit 4

1

4

High-throughput

0.479

High

766168

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.479

High

766169

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

766172

PRS10
26S proteasome regulatory subunit 10B

1

4

High-throughput

0.479

High

766177

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

766178

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

766180

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.479

High

766181

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

766182

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.479

High

766183

LAT1
Large neutral amino acids transporter small subunit 1

1

4

High-throughput

0.479

High

766188

RING1
E3 ubiquitin-protein ligase RING1

1

1

Small-scale

0.479

High

766192

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

766195

KRT81
Keratin, type II cuticular Hb1

1

1

High-throughput

0.479

High

766196

IMB1
Importin subunit beta-1

1

2

High-throughput

0.479

High

766197

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

766199

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.479

High

766201

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

766202

PCBP2
Poly(rC)-binding protein 2

1

2

High-throughput

0.479

High

766205

ELAV1
ELAV-like protein 1

1

3

Small-scale

0.479

High

766206

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

2

High-throughput

0.479

High

766210

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.479

High

766211

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

766212

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

766213

HS105
Heat shock protein 105 kDa

1

6

High-throughput

0.479

High

766217

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

766219

PSB7
Proteasome subunit beta type-7

1

3

High-throughput

0.479

High

766221

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

766223

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.479

High

766229

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

67459

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.458

High

182919

NKRF
NF-kappa-B-repressing factor

1

0

Small-scale

0.458

High

290873

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

346878

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

353041

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

358876

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.458

High

424586

PAI1
Plasminogen activator inhibitor 1

1

0

High-throughput

0.458

High

424791

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.458

High

427814

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.458

High

446700

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

467388

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

475277

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.458

High

484954

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

574154

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

612521

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

648099

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

697443

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

766144

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

766146

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.458

High

766154

FXR1
RNA-binding protein FXR1

1

0

Small-scale

0.458

High

766157

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

766158

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.458

High

766162

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

766164

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

766170

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

766171

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.458

High

766173

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

766174

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

766175

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

766179

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

766187

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

766189

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

766191

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.458

High

766194

FAT1
Protocadherin Fat 1

1

0

High-throughput

0.458

High

766198

PLEC
Plectin

1

0

High-throughput

0.458

High

766203

ELOC
Elongin-C

1

0

Small-scale

0.458

High

766204

ELOB
Elongin-B

1

0

High-throughput

0.458

High

766207

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.458

High

766208

SMN
Survival motor neuron protein

1

0

High-throughput

0.458

High

766209

HKDC1
Hexokinase HKDC1

1

0

High-throughput

0.458

High

766220

KLF6
Krueppel-like factor 6

1

0

Small-scale

0.458

High

766224

TBB6
Tubulin beta-6 chain

1

0

High-throughput

0.458

High

766225

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

0

High-throughput

0.458

High

766228

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

0

High-throughput

0.458

High

766230

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.458

High

766231

DICER
Endoribonuclease Dicer

1

0

High-throughput

0.458

High

766232

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

766233

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.458

High

229663

CALU
Calumenin

1

2

High-throughput

0.437

High

766155

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

766190

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.437

High

766227

HACD3
Very-long-chain

1

3

High-throughput

0.437

High

766235

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

1

High-throughput

0.437

High

766165

LYSC
Lysozyme C

1

0

Small-scale

0.426

High

766218

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

766151

PEX5
Peroxisomal targeting signal 1 receptor

1

0

Small-scale

0.391

High

766185

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.249

Low

766226

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025