Protein: RPF2
Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)

Gene: RPF2
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q9H7B2

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1065883

RRS1
Ribosome biogenesis regulatory protein homolog

4

2

High-throughput

0.900

High

1315944

MAK16
Protein MAK16 homolog

2

1

High-throughput

0.811

High

418670

NPM
Nucleophosmin

4

1

High-throughput

0.699

High

1332939

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.691

High

315425

NSA2
Ribosome biogenesis protein NSA2 homolog

3

1

High-throughput

0.667

High

842662

RL14
Large ribosomal subunit protein eL14

3

2

High-throughput

0.667

High

971348

H11
Histone H1.1

3

3

High-throughput

0.667

High

1316881

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

1

High-throughput

0.667

High

273255

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.656

High

347903

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

789545

RBM34
RNA-binding protein 34

2

2

High-throughput

0.628

High

900267

RL37A
Large ribosomal subunit protein eL43

2

1

High-throughput

0.628

High

914827

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

1

High-throughput

0.628

High

921979

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.628

High

942954

SRPK2
SRSF protein kinase 2

2

3

High-throughput

0.628

High

1076108

OASL
2'-5'-oligoadenylate synthase-like protein

2

1

High-throughput

0.628

High

1314619

RBM4
RNA-binding protein 4

2

2

High-throughput

0.628

High

1332925

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.628

High

1332926

H2AW
Core histone macro-H2A.2

2

2

High-throughput

0.628

High

489276

H14
Histone H1.4

2

3

High-throughput

0.611

High

923528

RL8
Large ribosomal subunit protein uL2

2

2

High-throughput

0.611

High

1085956

IF16
Gamma-interferon-inducible protein 16

2

1

High-throughput

0.611

High

1221463

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

1

High-throughput

0.609

High

196194

RRP8
Ribosomal RNA-processing protein 8

2

0

High-throughput

0.602

High

848130

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.602

High

1092621

KNOP1
Lysine-rich nucleolar protein 1

2

0

High-throughput

0.602

High

1264659

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

92309

E9PAV9
G patch domain-containing protein 4

2

2

High-throughput

0.584

High

323142

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

1018055

GRSF1
G-rich sequence factor 1

2

2

High-throughput

0.584

High

1332937

SRPK3
SRSF protein kinase 3

2

3

High-throughput

0.574

High

370446

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1269624

ESR2
Estrogen receptor beta

2

1

High-throughput

0.571

High

1332914

ANLN
Anillin

2

0

High-throughput

0.559

High

1077288

DLG2
Disks large homolog 2

2

1

High-throughput

0.553

High

1054099

GRB7
Growth factor receptor-bound protein 7

2

0

High-throughput

0.547

High

71241

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.536

High

269882

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

4

High-throughput

0.536

High

271417

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

281418

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.536

High

401111

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

559948

H12
Histone H1.2

1

3

High-throughput

0.536

High

641937

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.536

High

642601

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

736739

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

773568

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

781825

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

790562

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

802227

NOP2
Probable 28S rRNA

1

2

High-throughput

0.536

High

898484

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.536

High

899356

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

910572

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.536

High

913760

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

922390

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

923221

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

944944

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.536

High

989950

RL18
Large ribosomal subunit protein eL18

1

2

High-throughput

0.536

High

992935

SRSF1
Serine/arginine-rich splicing factor 1

1

3

High-throughput

0.536

High

1028821

SRSF5
Serine/arginine-rich splicing factor 5

1

4

High-throughput

0.536

High

1029096

SRSF6
Serine/arginine-rich splicing factor 6

1

6

High-throughput

0.536

High

1058036

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.536

High

1302046

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

1308770

RBM4B
RNA-binding protein 4B

1

2

High-throughput

0.536

High

1312525

ZN692
Zinc finger protein 692

1

1

High-throughput

0.536

High

1326256

REXO4
RNA exonuclease 4

1

1

High-throughput

0.536

High

1332909

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.536

High

1332922

RBM28
RNA-binding protein 28

1

3

High-throughput

0.536

High

1332923

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

398949

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

1063285

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

2

High-throughput

0.515

High

1129792

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

1

High-throughput

0.515

High

316158

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.513

High

585560

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

739836

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

801383

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

806685

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

1162459

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.513

High

1219001

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1270558

CDKL2
Cyclin-dependent kinase-like 2

1

0

High-throughput

0.513

High

1291195

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1295956

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1309626

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1332915

PRDM5
PR domain zinc finger protein 5

1

0

High-throughput

0.513

High

1332917

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

1332920

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1332933

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1332934

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1332935

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

265260

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

835997

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.493

High

999673

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

1332936

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.493

High

130275

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

1

High-throughput

0.489

High

485291

TZAP
Telomere zinc finger-associated protein

1

1

High-throughput

0.489

High

608637

H1T
Histone H1t

1

3

High-throughput

0.489

High

1332930

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.489

High

278876

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

379868

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

442496

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

582498

NUCL
Nucleolin

1

1

High-throughput

0.479

High

649739

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

760321

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

806176

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

890844

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

907525

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.479

High

916868

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.479

High

1034999

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

1045694

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.479

High

1054592

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

1135979

CE162
Centrosomal protein of 162 kDa

1

1

High-throughput

0.479

High

1136293

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1235652

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

1264189

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1315861

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1332910

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1332912

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

1332913

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

1332921

NLE1
Notchless protein homolog 1

1

1

High-throughput

0.479

High

1332924

AATF
Protein AATF

1

1

High-throughput

0.479

High

1332938

CE164
Centrosomal protein of 164 kDa

1

1

High-throughput

0.479

High

123009

MEN1
Menin

1

0

High-throughput

0.458

High

182908

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

210283

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

244943

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

258200

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

302600

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

360418

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.458

High

553723

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652261

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

665954

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.458

High

668988

PML
Protein PML

1

0

High-throughput

0.458

High

685031

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

721457

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

824383

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

893604

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

969994

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

999095

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1019642

ILF2
Interleukin enhancer-binding factor 2

1

0

High-throughput

0.458

High

1036086

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1199416

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

1201679

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1251027

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1256403

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1285761

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1294007

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1301225

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1301791

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

1304107

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

1332908

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1332911

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1332918

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1332927

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1332931

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.458

High

66850

A8KAG1
G patch domain-containing protein 4

1

2

High-throughput

0.445

High

931410

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.445

High

1057653

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

1133034

GPTC4
G patch domain-containing protein 4

1

2

High-throughput

0.445

High

1271028

DLG3
Disks large homolog 3

1

1

High-throughput

0.439

High

125716

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.437

High

324880

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

1

High-throughput

0.437

High

674529

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.437

High

1018357

MERTK
Tyrosine-protein kinase Mer

1

1

High-throughput

0.437

High

1146840

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

402481

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

351004

PDGFB
Platelet-derived growth factor subunit B

2

0

High-throughput

0.328

High

1311133

ZNF2
Zinc finger protein 2

2

0

High-throughput

0.328

High

1293511

PRR11
Proline-rich protein 11

2

0

High-throughput

0.318

High

256069

OBSL1
Obscurin-like protein 1

2

0

High-throughput

0.305

High

180455

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

841092

TUB
Tubby protein homolog

1

0

High-throughput

0.279

Low

1054918

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1101007

RN151
RING finger protein 151

1

0

High-throughput

0.279

Low

1193045

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

1201064

PNM8A
Paraneoplastic antigen-like protein 8A

1

0

High-throughput

0.279

Low

1201235

PIM3
Serine/threonine-protein kinase pim-3

1

0

High-throughput

0.279

Low

1295843

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1297840

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1298274

ZNF48
Zinc finger protein 48

1

0

High-throughput

0.279

Low

1332916

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

0

High-throughput

0.279

Low

1332932

IL17B
Interleukin-17B

1

0

High-throughput

0.279

Low

1332940

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

1236141

OTU6B
Deubiquitinase OTUD6B

1

0

High-throughput

0.269

Low

395777

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

119521

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

149295

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

298798

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

428438

TBB5
Tubulin beta chain

1

0

High-throughput

0.249

Low

530188

NCAM1
Neural cell adhesion molecule 1

1

0

High-throughput

0.249

Low

637293

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

780113

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

852623

RND2
Rho-related GTP-binding protein RhoN

1

0

High-throughput

0.249

Low

909127

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1053659

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1061619

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1066708

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1171732

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1203852

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1229855

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

1286701

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1289128

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.249

Low

1315149

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1316748

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1317622

RHBT2
Rho-related BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

1329086

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.249

Low

1330092

MTRFR
Mitochondrial translation release factor in rescue

1

0

High-throughput

0.249

Low

1332919

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

1332928

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.249

Low

306323

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

1134769

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1241621

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1332929

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024