HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRE (P23469)
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene: PTPRE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	unassigned2173
Identification Methods	ubiquitin reconstruction
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 700
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (1-697): 0: 883: 41.54
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (3-697): 0: 864: 42.21
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (13-700): 0: 863: 66.52
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (11-695): 0: 745: 32.78
+	Hs
		383597 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRA_HUMAN (13-700): 0: 863: 66.52
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (81-693): 0: 727: 37.96
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (7-694): 0: 712: 32.52
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (81-693): 0: 727: 37.96
+	Hs
		383612 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRG_HUMAN (11-695): 0: 745: 32.78
+	Hs
		146920 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRT_HUMAN (81-693): 0: 727: 37.96
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (409-695): 5.77e-113: 371: 36.81
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (336-692): 2.25e-108: 363: 30.66
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (416-692): 5.13e-107: 352: 36.56
+	Hs
		337903 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (119-409): 3.12e-76: 268: 30.63
+	Hs
		1071017 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRH_HUMAN (416-692): 5.13e-107: 352: 36.56
+	Hs
		383611 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRB_HUMAN (336-692): 2.25e-108: 363: 30.66
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (122-398): 9.09e-62: 226: 32.39
+	Hs
		383545 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRC_HUMAN (119-409): 3.12e-76: 268: 30.63
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (113-410): 2.17e-54: 204: 26.80