Protein: EREP1
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)

Gene: EREP1, ENTREP1
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q15884

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0022401 - negative adaptation of signaling pathway
GO:0031623 - receptor internalization
GO:0031901 - early endosome membrane
GO:0031902 - late endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1155186

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

6

15

High-throughput

0.734

High

1155174

ITCH
E3 ubiquitin-protein ligase Itchy homolog

5

15

Small-scale

0.718

High

861620

NEDD4
E3 ubiquitin-protein ligase NEDD4

5

15

High-throughput

0.714

High

1155176

NED4L
E3 ubiquitin-protein ligase NEDD4-like

5

15

Small-scale

0.711

High

1155154

AN13D
Ankyrin repeat domain-containing protein 13D

4

3

Small-scale

0.692

High

132069

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

7

15

Small-scale

0.680

High

321763

AGRL1
Adhesion G protein-coupled receptor L1

3

1

High-throughput

0.667

High

895350

S26A2
Sulfate transporter

3

1

High-throughput

0.667

High

1125842

FZD2
Frizzled-2

3

1

High-throughput

0.667

High

1155152

RHDF2
Inactive rhomboid protein 2

3

2

High-throughput

0.667

High

1155157

T179B
Transmembrane protein 179B

3

1

High-throughput

0.667

High

1155160

AN13A
Ankyrin repeat domain-containing protein 13A

3

3

High-throughput

0.667

High

1155162

SIDT2
SID1 transmembrane family member 2

3

1

High-throughput

0.667

High

1155181

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

3

1

High-throughput

0.667

High

1155182

S12A9
Solute carrier family 12 member 9

3

4

High-throughput

0.667

High

1155201

S12A6
Solute carrier family 12 member 6

3

4

High-throughput

0.667

High

1155203

KCNG1
Voltage-gated potassium channel regulatory subunit KCNG1

3

1

High-throughput

0.667

High

1155207

S12A4
Solute carrier family 12 member 4

3

4

High-throughput

0.667

High

320452

TM63A
Mechanosensitive cation channel TMEM63A

3

0

High-throughput

0.638

High

1155146

ANO6
Anoctamin-6

3

0

High-throughput

0.638

High

1155175

DNJC1
DnaJ homolog subfamily C member 1

3

0

High-throughput

0.638

High

1155192

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

3

0

High-throughput

0.638

High

990265

1433Z
14-3-3 protein zeta/delta

4

6

Small-scale

0.632

High

1155188

PCX3
Pecanex-like protein 3

4

1

Small-scale

0.632

High

1155198

HECW2
E3 ubiquitin-protein ligase HECW2

4

15

Small-scale

0.632

High

624635

SL9A1
Sodium/hydrogen exchanger 1

2

2

High-throughput

0.611

High

720415

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

2

3

High-throughput

0.611

High

294785

CAN15
Calpain-15

3

2

High-throughput

0.609

High

966358

1433G
14-3-3 protein gamma

3

6

High-throughput

0.609

High

1155155

STXB4
Syntaxin-binding protein 4

3

1

High-throughput

0.609

High

1155165

RHBL4
Rhomboid-related protein 4

3

2

High-throughput

0.609

High

1155195

CUED1
CUE domain-containing protein 1

3

1

High-throughput

0.609

High

1155197

WWOX
WW domain-containing oxidoreductase

3

1

High-throughput

0.609

High

1155210

RHBD3
Rhomboid domain-containing protein 3

3

4

High-throughput

0.609

High

296506

STAM2
Signal transducing adapter molecule 2

2

3

High-throughput

0.595

High

1155205

UBQL1
Ubiquilin-1

2

4

Small-scale

0.576

High

691041

1433T
14-3-3 protein theta

2

6

High-throughput

0.574

High

1155204

MYO6
Unconventional myosin-VI

2

1

Small-scale

0.562

High

790155

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

2

1

High-throughput

0.558

High

1103539

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

2

1

High-throughput

0.558

High

1095648

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

4

High-throughput

0.543

High

1093358

TRI32
E3 ubiquitin-protein ligase TRIM32

2

1

Small-scale

0.526

High

347723

BAG3
BAG family molecular chaperone regulator 3

2

2

Small-scale

0.526

High

1155214

EPN1
Epsin-1

1

2

Small-scale

0.506

High

729866

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.489

High

1155172

OPTN
Optineurin

1

0

High-throughput

0.486

High

603999

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

783040

CXG1
Gap junction gamma-1 protein

1

1

High-throughput

0.479

High

933411

S12A2
Solute carrier family 12 member 2

1

4

High-throughput

0.479

High

1155149

S27A3
Long-chain fatty acid transport protein 3

1

2

High-throughput

0.479

High

1155178

ABCA3
Phospholipid-transporting ATPase ABCA3

1

1

High-throughput

0.479

High

1155184

TTYH3
Protein tweety homolog 3

1

1

High-throughput

0.479

High

1155171

ASTRA
Protein Aster-A

1

0

High-throughput

0.458

High

1155189

S40A1
Ferroportin

1

0

Small-scale

0.458

High

135939

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

Small-scale

0.457

High

144012

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

1

1

Small-scale

0.457

High

329454

EPN2
Epsin-2

1

2

Small-scale

0.457

High

342889

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

Small-scale

0.457

High

507203

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

Small-scale

0.457

High

508036

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.457

High

987045

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

Small-scale

0.457

High

987366

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

Small-scale

0.457

High

1155179

UBAC1
Ubiquitin-associated domain-containing protein 1

1

4

Small-scale

0.457

High

730611

1433S
14-3-3 protein sigma

1

6

High-throughput

0.439

High

1046363

UBXN1
UBX domain-containing protein 1

1

5

High-throughput

0.439

High

1155158

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.439

High

1155147

GRAP1
GRIP1-associated protein 1

1

0

Small-scale

0.438

High

1155183

UBXN6
UBX domain-containing protein 6

1

0

Small-scale

0.438

High

337948

CNEP1
CTD nuclear envelope phosphatase 1

1

1

High-throughput

0.437

High

399687

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

High-throughput

0.437

High

1138962

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

16

High-throughput

0.437

High

1155163

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.437

High

1155190

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

325855

UBR5
E3 ubiquitin-protein ligase UBR5

1

16

Small-scale

0.417

High

853473

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

1

Small-scale

0.417

High

1155151

WWC2
Protein WWC2

1

14

Small-scale

0.417

High

1155156

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

15

Small-scale

0.417

High

1155168

SYNE2
Nesprin-2

1

1

Small-scale

0.417

High

1155169

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.417

High

1155191

UBQL4
Ubiquilin-4

1

4

Small-scale

0.417

High

1155194

RN216
E3 ubiquitin-protein ligase RNF216

1

2

Small-scale

0.417

High

1155206

POLI
DNA polymerase iota

1

1

Small-scale

0.417

High

1155208

POLH
DNA polymerase eta

1

1

Small-scale

0.417

High

1155213

ARI1
E3 ubiquitin-protein ligase ARIH1

1

2

Small-scale

0.417

High

1010468

EREP3
Protein ENTREP3

3

0

High-throughput

0.347

High

1155153

TMPPE
Transmembrane protein with metallophosphoesterase domain

3

0

High-throughput

0.347

High

1155161

GHDC
GH3 domain-containing protein

3

0

High-throughput

0.347

High

1155164

TBC15
TBC1 domain family member 15

3

0

High-throughput

0.347

High

1155166

CHPT1
Cholinephosphotransferase 1

3

0

High-throughput

0.347

High

1155196

CLDN1
Claudin domain-containing protein 1

3

0

High-throughput

0.347

High

1155180

CA043
Protein C1orf43

2

0

High-throughput

0.328

High

450240

HYEP
Epoxide hydrolase 1

2

0

High-throughput

0.318

High

773884

SOAT1
Sterol O-acyltransferase 1

2

0

High-throughput

0.318

High

1155193

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

2

0

High-throughput

0.318

High

1155209

KLH20
Kelch-like protein 20

2

0

High-throughput

0.318

High

971561

1433E
14-3-3 protein epsilon

2

0

Small-scale

0.316

High

1155199

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.279

Low

72657

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.249

Low

184989

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.249

Low

588798

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695564

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768290

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1155145

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.249

Low

1155148

MBRL
Membralin

1

0

High-throughput

0.249

Low

1155167

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.249

Low

1155200

FA8A1
Protein FAM8A1

1

0

High-throughput

0.249

Low

1155212

TBL2
Transducin beta-like protein 2

1

0

High-throughput

0.249

Low

175503

KHNYN
Protein KHNYN

1

0

Small-scale

0.238

Low

339166

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

Small-scale

0.238

Low

685204

PAX6
Paired box protein Pax-6

1

0

Small-scale

0.238

Low

1032317

OTUD4
OTU domain-containing protein 4

1

0

Small-scale

0.238

Low

1137717

TNIP1
TNFAIP3-interacting protein 1

1

0

Small-scale

0.238

Low

1155121

USF2
Upstream stimulatory factor 2

1

0

Small-scale

0.238

Low

1155150

RN123
E3 ubiquitin-protein ligase RNF123

1

0

Small-scale

0.238

Low

1155159

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.238

Low

1155170

CC127
Coiled-coil domain-containing protein 127

1

0

Small-scale

0.238

Low

1155173

DCNL1
DCN1-like protein 1

1

0

Small-scale

0.238

Low

1155177

UIMC1
BRCA1-A complex subunit RAP80

1

0

Small-scale

0.238

Low

1155185

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.238

Low

1155187

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

Small-scale

0.238

Low

1155202

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.238

Low

1155211

RN115
E3 ubiquitin-protein ligase RNF115

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025