HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 24189400, 8810340, 10766863, 24430869, 8610109, 11196191, 7542991, 23799367, 7506413, 25402006, 24658140, 28065597, 20473329, 16729043, 9388490, 26551075, 8665853, 25187647, 20067773, 9020193 and 30 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, protein complementation assay, enzymatic study, proximity labelling technology, unspecified method, protein kinase assay, experimental interaction detection, x-ray crystallography and 8 others

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Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0043066 - negative regulation of apoptotic process
and 5 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024