Protein: APOA1
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]

Gene: APOA1
Organism: Homo sapiens
Interactions: 198
UniProt ID: P02647

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001935 - endothelial cell proliferation
GO:0002719 - negative regulation of cytokine production involved in immune response
GO:0005102 - signaling receptor binding
GO:0005543 - phospholipid binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

387181

APOA1
Apolipoprotein A-I

12

3

Small-scale

0.982

High

387200

LCAT
Phosphatidylcholine-sterol acyltransferase

8

2

Small-scale

0.748

High

387203

A4
Amyloid-beta precursor protein

5

8

Small-scale

0.721

High

387307

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

4

3

High-throughput

0.709

High

337988

ABCA1
Phospholipid-transporting ATPase ABCA1

4

2

Small-scale

0.692

High

387182

APOA2
Apolipoprotein A-II

4

1

Small-scale

0.676

High

387198

APOB
Apolipoprotein B-100

3

2

Small-scale

0.656

High

366136

HPT
Haptoglobin

3

1

Small-scale

0.651

High

387273

MK06
Mitogen-activated protein kinase 6

3

0

High-throughput

0.646

High

387205

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

387183

APOC1
Apolipoprotein C-I

3

0

Small-scale

0.630

High

387246

SYUA
Alpha-synuclein

2

1

Small-scale

0.628

High

387298

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

2

1

High-throughput

0.628

High

387309

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

387228

LEG3
Galectin-3

2

3

Small-scale

0.611

High

387294

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.609

High

387311

ZN558
Zinc finger protein 558

3

1

High-throughput

0.609

High

387329

REN3A
Regulator of nonsense transcripts 3A

2

0

High-throughput

0.602

High

387257

CD81
CD81 antigen

2

1

Small-scale

0.601

High

387213

SAA2
Serum amyloid A-2 protein

2

3

Small-scale

0.586

High

387185

APOC3
Apolipoprotein C-III

2

0

High-throughput

0.585

High

387340

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

387184

APOC2
Apolipoprotein C-II

2

1

High-throughput

0.584

High

387260

PHLD
Phosphatidylinositol-glycan-specific phospholipase D

1

1

Small-scale

0.561

High

387300

SCRB1
Scavenger receptor class B member 1

1

1

Small-scale

0.561

High

387254

PLTP
Phospholipid transfer protein

1

2

Small-scale

0.550

High

387193

TRFE
Serotransferrin

2

0

High-throughput

0.547

High

387204

APOD
Apolipoprotein D

2

0

Small-scale

0.547

High

164893

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.541

High

387235

FBLN1
Fibulin-1

1

4

High-throughput

0.541

High

67418

GOG8A
Golgin subfamily A member 8A

1

2

High-throughput

0.536

High

132972

MATN2
Matrilin-2

1

1

High-throughput

0.536

High

210653

KLK10
Kallikrein-10

1

2

High-throughput

0.536

High

387186

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

1

High-throughput

0.536

High

387187

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.536

High

387188

C1QC
Complement C1q subcomponent subunit C

1

1

High-throughput

0.536

High

387192

ALBU
Albumin

1

2

High-throughput

0.536

High

387201

K2C1
Keratin, type II cytoskeletal 1

1

3

High-throughput

0.536

High

387210

K1C16
Keratin, type I cytoskeletal 16

1

2

High-throughput

0.536

High

387224

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

387230

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.536

High

387244

K1C9
Keratin, type I cytoskeletal 9

1

3

High-throughput

0.536

High

387259

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.536

High

387263

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

1

1

High-throughput

0.536

High

387269

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.536

High

387277

FBLN7
Fibulin-7

1

1

High-throughput

0.536

High

387279

TENS3
Tensin-3

1

1

High-throughput

0.536

High

387292

ABCA6
ATP-binding cassette sub-family A member 6

1

2

High-throughput

0.536

High

387305

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

387316

EGFL8
Epidermal growth factor-like protein 8

1

1

High-throughput

0.536

High

387322

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

387331

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

387339

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

387319

TMM43
Transmembrane protein 43

1

1

High-throughput

0.515

High

387342

SHLB1
Endophilin-B1

1

1

High-throughput

0.515

High

194443

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

231367

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.513

High

295415

CNMD
Leukocyte cell-derived chemotaxin 1

1

0

High-throughput

0.513

High

351635

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

361512

CERU
Ceruloplasmin

1

0

High-throughput

0.513

High

387189

FINC
Fibronectin

1

0

High-throughput

0.513

High

387191

TTHY
Transthyretin

1

0

High-throughput

0.513

High

387197

TDT
DNA nucleotidylexotransferase

1

0

High-throughput

0.513

High

387207

CATL1
Procathepsin L

1

0

High-throughput

0.513

High

387211

DHPR
Dihydropteridine reductase

1

0

High-throughput

0.513

High

387217

CLUS
Clusterin

1

0

High-throughput

0.513

High

387243

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

387247

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

387253

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.513

High

387256

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

387261

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

387262

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.513

High

387268

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.513

High

387276

FNDC1
Fibronectin type III domain-containing protein 1

1

0

High-throughput

0.513

High

387295

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

387297

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.513

High

387299

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.513

High

387301

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

387302

ASM3A
Cyclic GMP-AMP phosphodiesterase SMPDL3A

1

0

High-throughput

0.513

High

387308

MOCOS
Molybdenum cofactor sulfurase

1

0

High-throughput

0.513

High

387310

ROBO3
Roundabout homolog 3

1

0

High-throughput

0.513

High

387323

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

0

High-throughput

0.513

High

387326

SPEF2
Sperm flagellar protein 2

1

0

High-throughput

0.513

High

387332

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.513

High

387324

TRI15
E3 ubiquitin-protein ligase TRIM15

1

1

Small-scale

0.512

High

387285

BRAP
BRCA1-associated protein

1

1

Small-scale

0.508

High

387303

NDRG1
Protein NDRG1

1

0

Small-scale

0.504

High

387208

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

387286

ABCAD
ATP-binding cassette sub-family A member 13

1

2

Small-scale

0.501

High

387334

TREM2
Triggering receptor expressed on myeloid cells 2

1

1

Small-scale

0.501

High

387274

MA7D1
MAP7 domain-containing protein 1

1

1

High-throughput

0.494

High

387328

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.493

High

387220

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

387278

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

387287

TXND2
Thioredoxin domain-containing protein 2

1

1

High-throughput

0.489

High

387312

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

2

High-throughput

0.489

High

387337

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

387282

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.486

High

387242

AKT2
RAC-beta serine/threonine-protein kinase

1

2

High-throughput

0.481

High

387252

PDE1A
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

1

1

Small-scale

0.481

High

387202

VWF
von Willebrand factor

1

0

Small-scale

0.480

High

387209

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

0

High-throughput

0.479

High

127237

LEG8
Galectin-8

1

3

Small-scale

0.479

High

323074

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

369286

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.479

High

369418

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.479

High

369568

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.479

High

387194

HEMO
Hemopexin

1

2

High-throughput

0.479

High

387199

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

387212

SAA1
Serum amyloid A-1 protein

1

3

High-throughput

0.479

High

387216

TFPI1
Tissue factor pathway inhibitor

1

5

High-throughput

0.479

High

387218

K2C3
Keratin, type II cytoskeletal 3

1

3

High-throughput

0.479

High

387221

MYH6
Myosin-6

1

1

High-throughput

0.479

High

387222

CO6
Complement component C6

1

2

High-throughput

0.479

High

387226

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

High-throughput

0.479

High

387229

LBP
Lipopolysaccharide-binding protein

1

2

Small-scale

0.479

High

387231

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

1

High-throughput

0.479

High

387238

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

387245

SAA4
Serum amyloid A-4 protein

1

3

High-throughput

0.479

High

387258

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.479

High

387264

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.479

High

387265

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

387275

K2C71
Keratin, type II cytoskeletal 71

1

2

High-throughput

0.479

High

387289

K2C73
Keratin, type II cytoskeletal 73

1

2

High-throughput

0.479

High

387304

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

387321

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

387325

TRIM6
Tripartite motif-containing protein 6

1

1

Small-scale

0.479

High

387343

TLN1
Talin-1

1

3

High-throughput

0.479

High

387215

OSTP
Osteopontin

1

0

High-throughput

0.460

High

387251

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.460

High

387317

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

318565

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.458

High

387190

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

387195

STAT
Statherin

1

0

High-throughput

0.458

High

387196

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

387206

ITB2
Integrin beta-2

1

0

High-throughput

0.458

High

387223

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

387225

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

387232

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.458

High

387233

FLNA
Filamin-A

1

0

High-throughput

0.458

High

387237

MOES
Moesin

1

0

High-throughput

0.458

High

387240

CD40L
CD40 ligand

1

0

Small-scale

0.458

High

387241

LCN1
Lipocalin-1

1

0

High-throughput

0.458

High

387248

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

387255

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

387270

CUL7
Cullin-7

1

0

High-throughput

0.458

High

387272

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

387290

PLDX1
Plexin domain-containing protein 1

1

0

High-throughput

0.458

High

387296

NNRE
NAD(P)H-hydrate epimerase

1

0

Small-scale

0.458

High

387313

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

387336

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.458

High

387344

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

387345

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.458

High

387234

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.457

High

229256

ANGL7
Angiopoietin-related protein 7

1

1

High-throughput

0.445

High

379060

IGKC
Immunoglobulin kappa constant

1

3

High-throughput

0.445

High

379178

IGHG1
Immunoglobulin heavy constant gamma 1

1

3

High-throughput

0.445

High

379481

IGHM
Immunoglobulin heavy constant mu

1

3

High-throughput

0.445

High

379596

IGHA1
Immunoglobulin heavy constant alpha 1

1

3

High-throughput

0.445

High

387227

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.445

High

277234

PITX3
Pituitary homeobox 3

1

1

Small-scale

0.437

High

360701

COX3
Cytochrome c oxidase subunit 3

1

1

Small-scale

0.437

High

387219

MYH7
Myosin-7

1

1

High-throughput

0.437

High

387283

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.437

High

387291

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

387314

EYA1
Protein phosphatase EYA1

1

1

High-throughput

0.437

High

387327

ASXL3
Putative Polycomb group protein ASXL3

1

3

High-throughput

0.437

High

164710

APOL1
Apolipoprotein L1

1

0

Small-scale

0.426

High

219585

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.426

High

261049

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

296898

DGAT1
Diacylglycerol O-acyltransferase 1

1

0

Small-scale

0.426

High

378752

KVD40
Immunoglobulin kappa variable 2D-40

1

0

High-throughput

0.426

High

387236

CRHBP
Corticotropin-releasing factor-binding protein

1

0

High-throughput

0.426

High

387249

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.426

High

387266

APOF
Apolipoprotein F

1

0

Small-scale

0.426

High

387330

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

387271

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.282

High

387335

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.282

High

319044

K0754
Microtubule-actin cross-linking factor 1, isoforms 6/7

1

0

High-throughput

0.279

Low

355391

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

High-throughput

0.279

Low

387281

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

387284

SETX
Probable helicase senataxin

1

0

High-throughput

0.279

Low

387288

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

387293

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

0

High-throughput

0.279

Low

387306

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

387315

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

387318

FA83C
Protein FAM83C

1

0

High-throughput

0.279

Low

387333

KLH28
Kelch-like protein 28

1

0

High-throughput

0.279

Low

387338

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.279

Low

387341

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.279

Low

387346

F169A
Soluble lamin-associated protein of 75 kDa

1

0

High-throughput

0.279

Low

387239

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

387250

CNN1
Calponin-1

1

0

High-throughput

0.249

Low

387267

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

387280

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low

387214

POK10
Endogenous retrovirus group K member 10 Pol protein

1

0

High-throughput

0.232

Low

387320

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025