HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S10A7 (P31151)
Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)
Gene: S100A7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	16799092
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 101
+	Hs
		338660 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HORN_HUMAN (2-101): 3.64e-31: 116: 18.45
+	Hs
		338220 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AA_HUMAN (2-90): 1.26e-31: 108: 23.60
+	Hs
		338011 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AB_HUMAN (2-95): 3.52e-31: 107: 32.99
+	Hs
		337773 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A9_HUMAN (4-101): 4.09e-28: 99: 23.53
+	Hs
		337962 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A4_HUMAN (2-92): 2.19e-27: 97.7: 23.40
+	Hs
		893799 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AA_HUMAN (2-90): 1.26e-31: 108: 23.60
+	Hs
		685170 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AB_HUMAN (2-95): 3.52e-31: 107: 32.99
+	Hs
		642945 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10A4_HUMAN (2-92): 2.19e-27: 97.7: 23.40
+	Hs
		383643 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AB_HUMAN (2-95): 3.52e-31: 107: 32.99
+	Hs
		383930 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AG_HUMAN (4-98): 1.78e-23: 88: 26.26
+	Hs
		601869 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10AA_HUMAN (2-90): 1.26e-31: 108: 23.60
+	Hs
		383989 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AE_HUMAN (4-84): 2.54e-18: 74.9: 21.69
+	Hs
		601812 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10A4_HUMAN (2-92): 2.19e-27: 97.7: 23.40
+	Hs
		380734 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S100B_HUMAN (4-93): 2.11e-25: 92.3: 24.73
+	Hs
		416337 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		S10A9_HUMAN (4-101): 4.09e-28: 99: 23.53
+	Hs
		396674 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		S10A8_HUMAN (2-94): 6.39e-23: 86.1: 22.92