HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 25043298, 28205554, 35384245
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, proximity labelling technology
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_M~PK_Tyr_Ser-Thr
Common GO terms GO:0005178 - integrin binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0016020 - membrane
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024