Protein: PSN2
Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]

Gene: PSN2, PSEN2
Organism: Homo sapiens
Interactions: 102
UniProt ID: P49810

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0001666 - response to hypoxia
GO:0005637 - nuclear inner membrane
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834244

PSN1
Presenilin-1

3

7

Small-scale

0.850

High

394345

A4
Amyloid-beta precursor protein

3

2

Small-scale

0.843

High

834998

APH1A
Gamma-secretase subunit APH-1A

3

10

Small-scale

0.839

High

835012

PEN2
Gamma-secretase subunit PEN-2

3

7

Small-scale

0.827

High

834994

APH1B
Gamma-secretase subunit APH-1B

2

10

Small-scale

0.754

High

835014

UBQL1
Ubiquilin-1

3

3

Small-scale

0.672

High

834995

NICA
Nicastrin

3

6

Small-scale

0.650

High

835005

CIB1
Calcium and integrin-binding protein 1

2

4

Small-scale

0.628

High

835017

CSEN
Calsenilin

2

4

Small-scale

0.620

High

834952

PSN2
Presenilin-2

1

7

Small-scale

0.618

High

835018

TRAF6
TNF receptor-associated factor 6

2

1

Small-scale

0.601

High

834982

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.590

High

835006

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.590

High

675306

SORCN
Sorcin

1

2

Small-scale

0.578

High

261226

FLNB
Filamin-B

1

5

Small-scale

0.573

High

834962

B2CL1
Bcl-2-like protein 1

1

4

Small-scale

0.573

High

834968

FHL2
Four and a half LIM domains protein 2

1

0

Small-scale

0.561

High

834969

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.557

High

427864

CAN1
Calpain-1 catalytic subunit

1

2

Small-scale

0.552

High

834984

KCIP4
Kv channel-interacting protein 4

1

4

Small-scale

0.552

High

636275

DNJB1
DnaJ homolog subfamily B member 1

1

3

High-throughput

0.541

High

834973

RHEB
GTP-binding protein Rheb

1

2

High-throughput

0.541

High

834990

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.518

High

835016

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.518

High

282317

NEBL
Nebulette

1

1

High-throughput

0.515

High

364847

FRIL
Ferritin light chain

1

1

High-throughput

0.515

High

655271

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.515

High

834959

H31
Histone H3.1

1

1

High-throughput

0.515

High

834964

PDZ1I
PDZK1-interacting protein 1

1

1

High-throughput

0.515

High

834976

BAK
Bcl-2 homologous antagonist/killer

1

4

High-throughput

0.515

High

834978

SGSM1
Small G protein signaling modulator 1

1

1

High-throughput

0.515

High

834992

HUMMR
Protein MGARP

1

1

High-throughput

0.515

High

834991

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.513

High

835019

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

598013

FLNA
Filamin-A

1

5

Small-scale

0.506

High

212607

AP1G1
AP-1 complex subunit gamma-1

1

1

Small-scale

0.501

High

834958

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

835013

ICAM5
Intercellular adhesion molecule 5

1

2

Small-scale

0.501

High

835009

RNF32
RING finger protein 32

1

1

High-throughput

0.494

High

835011

FXL12
F-box/LRR-repeat protein 12

1

1

High-throughput

0.494

High

835020

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.493

High

667438

CASP1
Caspase-1

1

0

High-throughput

0.493

High

834993

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.493

High

835007

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.493

High

835010

S6A13
Sodium- and chloride-dependent GABA transporter 2

1

0

High-throughput

0.493

High

157431

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.481

High

667667

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.481

High

834965

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

1

High-throughput

0.481

High

834967

AAMP
Angio-associated migratory cell protein

1

3

High-throughput

0.481

High

834997

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.481

High

160450

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

656358

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.480

High

821939

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.480

High

197889

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

Small-scale

0.479

High

331375

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

4

Small-scale

0.479

High

489386

BCL2
Apoptosis regulator Bcl-2

1

4

Small-scale

0.479

High

834953

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.479

High

834956

TSN5
Tetraspanin-5

1

1

High-throughput

0.479

High

834960

DLK1
Protein delta homolog 1

1

11

High-throughput

0.479

High

834961

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

4

Small-scale

0.479

High

834970

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

Small-scale

0.479

High

834972

KIF22
Kinesin-like protein KIF22

1

1

High-throughput

0.479

High

834977

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

835000

FAF2
FAS-associated factor 2

1

1

High-throughput

0.479

High

835004

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

4

Small-scale

0.479

High

59945

A4FUJ8
MKL1 protein

1

1

High-throughput

0.470

High

297731

MICA2
[F-actin]-monooxygenase MICAL2

1

5

High-throughput

0.470

High

834963

ARL16
ADP-ribosylation factor-like protein 16

1

3

High-throughput

0.470

High

834986

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.470

High

835001

MR1L1
MORF4 family-associated protein 1-like 1

1

1

High-throughput

0.470

High

835002

ZMAT2
Zinc finger matrin-type protein 2

1

1

High-throughput

0.470

High

835008

SKI8
Superkiller complex protein 8

1

3

High-throughput

0.470

High

235269

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.460

High

834957

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.460

High

834974

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.460

High

834983

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.460

High

834989

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.460

High

834966

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

High-throughput

0.458

High

835015

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.458

High

834975

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.445

High

535350

GFAP
Glial fibrillary acidic protein

1

1

Small-scale

0.439

High

421283

LIPF
Gastric triacylglycerol lipase

1

0

High-throughput

0.282

High

833693

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.269

Low

834971

IRF3
Interferon regulatory factor 3

1

0

High-throughput

0.269

Low

130148

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.268

Low

313691

SOX14
Transcription factor SOX-14

1

0

High-throughput

0.268

Low

781717

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.268

Low

834954

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.268

Low

834979

ZXDC
Zinc finger protein ZXDC

1

0

High-throughput

0.268

Low

834980

SP6
Transcription factor Sp6

1

0

High-throughput

0.268

Low

834981

FX4L6
Forkhead box protein D4-like 6

1

0

High-throughput

0.268

Low

834985

Q86WV2
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.268

Low

834987

ZN366
Zinc finger protein 366

1

0

High-throughput

0.268

Low

834988

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.268

Low

835003

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.268

Low

835021

EID1
EP300-interacting inhibitor of differentiation 1

1

0

High-throughput

0.265

Low

327647

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.251

Low

728570

CHKA
Choline kinase alpha

1

0

High-throughput

0.251

Low

834996

HPS1
BLOC-3 complex member HPS1

1

0

High-throughput

0.251

Low

834999

EVI5L
EVI5-like protein

1

0

High-throughput

0.251

Low

834955

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024