HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RBM25 (P49756)
RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)
Gene: RBM25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24189400, 28065597
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 843
+	Hs
		338037 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYH9_HUMAN (151-803): 4.55e-19: 95.3: 9.50
+	Hs
		254427 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ROCK2_HUMAN (55-790): 3.56e-18: 92.2: 9.38
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (3-678): 5.19e-14: 78.7: 10.77
+	Hs
		338508 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRDN_HUMAN (116-772): 9.29e-12: 71.4: 11.87
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (394-779): 1.8e-11: 70.2: 12.34
+	Hs
		383566 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		NFH_HUMAN (205-769): 6.62e-12: 71.8: 11.50
+	Hs
		383838 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRDN_HUMAN (116-772): 9.29e-12: 71.4: 11.87
+	Hs
		665646 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		LRIQ1_HUMAN (122-709): 5.86e-23: 107: 10.46
+	Hs
		1072575 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		LRIQ1_HUMAN (122-709): 5.86e-23: 107: 10.46
+	Hs
		665312 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		LRIQ1_HUMAN (122-709): 5.86e-23: 107: 10.46
+	Hs
		665419 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		LRIQ1_HUMAN (122-709): 5.86e-23: 107: 10.46
+	Hs
		665375 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MYH9_HUMAN (151-803): 4.55e-19: 95.3: 9.50
+	Hs
		665608 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ITSN1_HUMAN (394-779): 1.8e-11: 70.2: 12.34
+	Hs
		665595 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ROCK1_HUMAN (233-825): 4.43e-10: 65.6: 9.78
+	Hs
		411404 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		GRDN_HUMAN (116-772): 9.29e-12: 71.4: 11.87
+	Hs
		833414 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		RBM25_HUMAN (1-843): 8.68e-63: 229: 100.00
+	Mm
		222875 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH9_MOUSE (140-803): 1.16e-18: 93.7: 9.64
+	Mm
		222845 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH10_MOUSE (228-817): 2.81e-13: 76.4: 9.32