HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	24189400, 7534311, 35384245, 23956138, 24797263
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030669 - clathrin-coated endocytic vesicle membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 937
+	Mm
		193237 EGFR_MOUSE (1-1210): 0: 1258: 90.35		AP1B1_MOUSE (1-937): 0: 883: 83.88
+	Hs
		338339 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		383731 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Mm
		567498 EGFR_MOUSE (1-1210): 0: 1258: 90.35		AP2A1_MOUSE (11-932): 0: 633: 17.04
+	Hs
		321451 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302078 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		212580 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Hs
		276351 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1G2_HUMAN (11-698): 4e-162: 496: 14.73
+	Hs
		383781 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AP3B2_HUMAN (16-594): 2.55e-174: 537: 28.71
+	Hs
		665202 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Rn
		102587 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		G3V9N8_RAT (1-937): 0: 876: 84.08
+	Hs
		321491 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		411342 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		COPB_HUMAN (8-927): 0: 561: 12.47
+	Rn
		544774 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		COPB_RAT (8-927): 0: 559: 12.47
+	Rn
		71352 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B2RYN6_RAT (11-808): 9.07e-174: 527: 17.45
+	Gg
		94462 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		COPB_CHICK (8-927): 0: 560: 12.56