Protein: CLD2
Claudin-2 (SP82)

Gene: CLD2, CLDN2
Organism: Homo sapiens
Interactions: 34
UniProt ID: P57739

Gene Ontology (top 5):
GO:0002227 - innate immune response in mucosa
GO:0005198 - structural molecule activity
GO:0005654 - nucleoplasm
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932725

EMP3
Epithelial membrane protein 3

2

5

High-throughput

0.783

High

945180

BT3A2
Butyrophilin subfamily 3 member A2

2

3

High-throughput

0.783

High

220366

LAT
Linker for activation of T-cells family member 1

2

2

High-throughput

0.606

High

945177

MYPR
Myelin proteolipid protein

2

1

High-throughput

0.606

High

945187

GRM2
Metabotropic glutamate receptor 2

2

1

High-throughput

0.606

High

945199

LPAR3
Lysophosphatidic acid receptor 3

2

6

High-throughput

0.606

High

945201

CLC2D
C-type lectin domain family 2 member D

2

7

High-throughput

0.606

High

945190

I27RA
Interleukin-27 receptor subunit alpha

2

0

High-throughput

0.580

High

70156

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

665962

IBP5
Insulin-like growth factor-binding protein 5

2

5

High-throughput

0.553

High

945183

CXCL9
C-X-C motif chemokine 9

2

2

High-throughput

0.553

High

945184

KRA11
Keratin-associated protein 1-1

2

3

High-throughput

0.553

High

945189

F209A
Protein FAM209A

2

2

High-throughput

0.553

High

945192

KRA13
Keratin-associated protein 1-3

2

3

High-throughput

0.553

High

945188

K1H1
Keratin, type I cuticular Ha1

1

2

High-throughput

0.523

High

945191

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.523

High

945195

AP2M1
AP-2 complex subunit mu

1

0

Small-scale

0.513

High

945182

ZO1
Tight junction protein 1

1

20

Small-scale

0.501

High

945196

KR412
Keratin-associated protein 4-12

1

3

High-throughput

0.494

High

945186

SQSTM
Sequestosome-1

1

0

Small-scale

0.493

High

945200

ZO2
Tight junction protein 2

1

20

Small-scale

0.481

High

945185

Q08AM2
ADAM33 protein

1

2

High-throughput

0.470

High

297780

PIAS2
E3 SUMO-protein ligase PIAS2

1

0

Small-scale

0.460

High

945179

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.460

High

344660

AP2A1
AP-2 complex subunit alpha-1

1

1

Small-scale

0.445

High

561973

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

Small-scale

0.445

High

945178

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.439

High

945194

LNX1
E3 ubiquitin-protein ligase LNX

1

7

Small-scale

0.439

High

945197

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

2

High-throughput

0.439

High

945181

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.426

High

60564

TM218
Transmembrane protein 218

2

0

High-throughput

0.316

High

945193

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.316

High

945202

TX264
Testis-expressed protein 264

2

0

High-throughput

0.316

High

945198

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025