HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	28065597, 25754235
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BIR~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043066 - negative regulation of apoptotic process GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 497
+	Hs
		383741 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		338383 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		338382 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		338580 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		338889 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CGRF1_HUMAN (317-491): 2.2e-23: 102: 14.29
+	Hs
		957688 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		434233 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		665280 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68