HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	25402006, 24658140, 28065597, 20029029, unassigned2173, 21376233
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, bimolecular fluorescence complementation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0071364 - cellular response to epidermal growth factor stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 780
+	Mm
		728828 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		337903 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		338901 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN18_HUMAN (14-446): 4.35e-123: 378: 32.66
+	Hs
		337897 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (7-295): 3.58e-101: 329: 31.54
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (8-299): 1.81e-94: 325: 32.32
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (8-296): 7.41e-63: 231: 25.93
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (7-293): 8.06e-59: 219: 21.36
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		338510 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN20_HUMAN (52-300): 3e-43: 164: 36.76
+	Hs
		338025 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN7_HUMAN (58-298): 7.19e-43: 161: 38.93