HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34591612, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 457
+	Hs
		338303 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		383783 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118663 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		338429 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		338010 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118667 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		923826 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73
+	Hs
		383803 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		383642 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		383729 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73
+	Hs
		601874 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73
+	Hs
		983602 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118676 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		537736 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Rn
		193482 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		STIP1_RAT (265-457): 1.25e-22: 102: 18.14
+	Hs
		411467 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	Hs
		684651 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118686 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		537740 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		435726 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51