HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	10648629, 10913131, 19401591, 25402006, 24658140, 9890893, 23066441, 11432805, 35384245, 18271526, unassigned2173, 21278788
Identification Methods	affinity chromatography technology, pull down, two hybrid, protein complementation assay, enzymatic study, proximity labelling technology, ubiquitin reconstruction, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0007173 - epidermal growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 694
+	Hs
		339151 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		383784 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		338819 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOC10_HUMAN (6-571): 2.68e-119: 395: 14.59
+	Hs
		384030 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		338561 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		338998 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		338764 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CNKR2_HUMAN (7-393): 3.45e-59: 217: 16.63
+	Hs
		339001 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		339053 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLEK2_HUMAN (3-111): 6.36e-16: 81.7: 28.95
+	Hs
		602027 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DAPP1_HUMAN (8-129): 2.12e-16: 82.1: 25.40
+	Hs
		434188 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		724173 RET_MOUSE (420-1058): 5.27e-125: 414: 22.14		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		872642 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665596 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665234 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665661 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		1072602 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872712 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		665662 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		1072603 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49