HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26320552
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005516 - calmodulin binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030054 - cell junction GO:0045296 - cadherin binding and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 2472
+	Hs
		338442 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		211452 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		383754 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		601922 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		383972 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SPTN4_HUMAN (961-2371): 1.09e-21: 105: 13.80
+	Hs
		665216 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		665392 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Rn
		88537 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D3ZC56_RAT (1-1395): 1.08e-13: 80.1: 11.19
+	Mm
		222846 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		SPTB2_MOUSE (1408-2420): 1.22e-29: 132: 18.86