HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: I13R2 (Q14627)
Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
Gene: IL13RA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	29203859
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 380
+	Hs
		338290 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IL5RA_HUMAN (11-374): 1.63e-68: 223: 24.34
+	Hs
		383808 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		I13R2_HUMAN (1-380): 6.74e-94: 287: 100.00
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (13-345): 1.32e-32: 131: 11.95
+	Mm
		250890 EGFR_MOUSE (1-1210): 0: 1258: 90.35		OSMR_MOUSE (80-361): 1.12e-19: 93: 14.53
+	Hs
		338888 EGFR_HUMAN (1-1210): 0: 1241: 100.00		OSMR_HUMAN (140-361): 1.05e-18: 89.9: 15.65
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (4-241): 4.11e-16: 82.5: 10.98
+	Hs
		383710 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHA5_HUMAN (5-363): 1.85e-59: 209: 13.49
+	Hs
		338057 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IL6RB_HUMAN (48-374): 4.53e-15: 78.7: 12.05
+	Hs
		383631 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHA3_HUMAN (23-337): 2.87e-58: 205: 13.60
+	Hs
		383712 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHA4_HUMAN (18-333): 1.19e-57: 204: 12.35
+	Hs
		338085 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LIFR_HUMAN (139-357): 4.11e-11: 66.8: 17.80
+	Hs
		383711 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHB1_HUMAN (5-363): 1.45e-54: 195: 15.12
+	Hs
		383632 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHB2_HUMAN (13-368): 3.87e-53: 191: 14.25
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (30-130): 3.77e-09: 60.9: 10.58
+	Hs
		383948 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		OSMR_HUMAN (140-361): 1.05e-18: 89.9: 15.65
+	Hs
		383660 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IL6RB_HUMAN (48-374): 4.53e-15: 78.7: 12.05
+	Hs
		601828 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		IL6RB_HUMAN (48-374): 4.53e-15: 78.7: 12.05
+	Hs
		665567 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		EPHB2_HUMAN (13-368): 3.87e-53: 191: 14.25
+	Mm
		872617 EPHB2_MOUSE (640-1067): 7.47e-121: 400: 28.09		EPHB2_MOUSE (13-368): 6.14e-53: 190: 14.51
+	Hs
		434120 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTPRF_HUMAN (4-241): 4.11e-16: 82.5: 10.98