HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CE170 (Q5SW79)
Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)
Gene: CEP170

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1584
+	Hs
		338878 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC4_HUMAN (165-1560): 2.05e-33: 144: 9.47
+	Hs
		338965 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TARA_HUMAN (287-1532): 3.13e-27: 123: 8.21
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (252-1467): 8.36e-24: 112: 8.68
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (1087-1574): 2.68e-22: 106: 10.61
+	Hs
		339147 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRRM2_HUMAN (122-1517): 1.29e-18: 95.3: 9.74
+	Hs
		338874 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MINT_HUMAN (173-1570): 1.59e-17: 91.8: 7.72
+	Hs
		338765 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC16_HUMAN (125-1565): 8.32e-16: 86.3: 10.01
+	Hs
		338292 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK2_HUMAN (318-1298): 5e-14: 80.2: 13.65
+	Hs
		338620 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MICA3_HUMAN (662-1403): 1.36e-13: 78.7: 12.99
+	Hs
		1071005 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC4_HUMAN (165-1560): 2.05e-33: 144: 9.47
+	Hs
		601846 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MAP1B_HUMAN (175-1557): 2.54e-45: 183: 9.56
+	Hs
		383946 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC4_HUMAN (165-1560): 2.05e-33: 144: 9.47
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (1087-1574): 2.68e-22: 106: 10.61
+	Hs
		601984 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC4_HUMAN (165-1560): 2.05e-33: 144: 9.47
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (1087-1574): 2.68e-22: 106: 10.61
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (1087-1574): 2.68e-22: 106: 10.61
+	Mm
		222852 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		CE170_MOUSE (1-1584): 0: 592: 88.00
+	Dm
		1001998 Q0KIF4_DROME (621-1017): 1.89e-113: 382: 32.07		Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84
+	Hs
		665581 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK2_HUMAN (318-1298): 5e-14: 80.2: 13.65
+	Mm
		222869 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		ANK2_MOUSE (123-1379): 8.94e-11: 69.4: 13.83