HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MPP7 (Q5T2T1)
MAGUK p55 subfamily member 7
Gene: MPP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0030054 - cell junction GO:0045296 - cadherin binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 576
+	Hs
		338283 EGFR_HUMAN (1-1210): 0: 1241: 100.00		EM55_HUMAN (78-575): 3.3e-116: 354: 31.28
+	Mm
		1142638 ERBB4_MOUSE (7-1199): 0: 1146: 49.53		DLG4_MOUSE (91-225): 1.04e-21: 101: 16.08
+	Hs
		1021496 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG1_HUMAN (2-228): 9.88e-24: 108: 16.33
+	Hs
		1070968 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG2_HUMAN (62-221): 2.34e-23: 107: 15.66
+	Hs
		942346 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG4_HUMAN (91-431): 7.29e-22: 102: 12.50
+	Hs
		1070994 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG3_HUMAN (139-485): 4.74e-17: 87: 10.74
+	Hs
		383736 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DLG4_HUMAN (91-431): 7.29e-22: 102: 12.50
+	Hs
		1072518 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		MPP7_HUMAN (1-576): 5.36e-166: 486: 100.00
+	Hs
		159179 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		CSKP_HUMAN (1-575): 8.86e-131: 406: 30.33
+	Hs
		159214 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		CSKP_HUMAN (1-575): 8.86e-131: 406: 30.33
+	Rn
		88514 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		MPP2_RAT (1-575): 3.88e-143: 427: 34.93
+	Hs
		872639 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		DLG1_HUMAN (2-228): 9.88e-24: 108: 16.33
+	Hs
		1021499 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		DLG1_HUMAN (2-228): 9.88e-24: 108: 16.33
+	Mm
		710140 FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68		DLG4_MOUSE (91-225): 1.04e-21: 101: 16.08
+	Mm
		796509 ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00		DLG1_MOUSE (2-228): 1.15e-24: 110: 14.46