Protein: KMT2C
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)

Gene: KMT2C
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q8NEZ4

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243848

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

13

20

Small-scale

0.982

High

1070746

RBBP5
Retinoblastoma-binding protein 5

11

20

Small-scale

0.978

High

903374

WDR5
WD repeat-containing protein 5

10

20

Small-scale

0.975

High

917621

H4
Histone H4

4

14

Small-scale

0.888

High

183137

KDM6A
Lysine-specific demethylase 6A

3

20

Small-scale

0.847

High

935004

H31
Histone H3.1

3

20

Small-scale

0.845

High

1174600

H32
Histone H3.2

2

20

Small-scale

0.778

High

1057773

NCOA6
Nuclear receptor coactivator 6

6

20

Small-scale

0.734

High

150104

UTY
Histone demethylase UTY

1

20

High-throughput

0.691

High

516595

PABP1
Polyadenylate-binding protein 1

1

14

High-throughput

0.665

High

1173188

PAXI1
PAX-interacting protein 1

3

20

Small-scale

0.662

High

1243838

PAGR1
PAXIP1-associated glutamate-rich protein 1

3

2

Small-scale

0.656

High

391802

H2A1B
Histone H2A type 1-B/E

1

20

Small-scale

0.647

High

707690

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.647

High

1086228

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

928397

DYL1
Dynein light chain 1, cytoplasmic

2

4

High-throughput

0.628

High

152667

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.618

High

165699

SET1A
Histone-lysine N-methyltransferase SETD1A

1

18

High-throughput

0.618

High

211213

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

301148

KDM4B
Lysine-specific demethylase 4B

1

14

Small-scale

0.618

High

918533

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

952479

H33
Histone H3.3

1

20

Small-scale

0.618

High

975285

KMT2A
Histone-lysine N-methyltransferase 2A

1

18

High-throughput

0.618

High

1080127

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.618

High

1140633

RN123
E3 ubiquitin-protein ligase RNF123

1

20

High-throughput

0.618

High

1166697

WDR82
WD repeat-containing protein 82

1

20

Small-scale

0.618

High

1243846

CXXC1
CXXC-type zinc finger protein 1

1

20

High-throughput

0.618

High

1243852

KMT2B
Histone-lysine N-methyltransferase 2B

1

17

High-throughput

0.618

High

1243853

SET1B
Histone-lysine N-methyltransferase SETD1B

1

17

High-throughput

0.618

High

1243833

DYL2
Dynein light chain 2, cytoplasmic

2

4

High-throughput

0.611

High

1243840

DPY30
Protein dpy-30 homolog

2

8

Small-scale

0.595

High

1243507

DP13B
DCC-interacting protein 13-beta

2

8

High-throughput

0.594

High

228101

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

370040

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

402260

JUN
Transcription factor Jun

1

10

High-throughput

0.541

High

1082593

MK14
Mitogen-activated protein kinase 14

1

2

High-throughput

0.541

High

987995

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.536

High

1158284

CDC73
Parafibromin

1

5

Small-scale

0.536

High

1017175

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

9

Small-scale

0.527

High

353445

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.517

High

340813

KAD1
Adenylate kinase isoenzyme 1

1

3

High-throughput

0.515

High

653667

CALR
Calreticulin

1

5

High-throughput

0.515

High

1034094

TCOF
Treacle protein

1

20

High-throughput

0.515

High

1077313

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.508

High

387139

P53
Cellular tumor antigen p53

1

8

Small-scale

0.500

High

1243836

ERP44
Endoplasmic reticulum resident protein 44

1

8

High-throughput

0.489

High

68299

P20L1
PHD finger protein 20-like protein 1

1

12

High-throughput

0.479

High

118368

HAX1
HCLS1-associated protein X-1

1

1

Small-scale

0.479

High

122888

MEN1
Menin

1

8

High-throughput

0.479

High

135133

NFIB
Nuclear factor 1 B-type

1

16

High-throughput

0.479

High

171052

TBXT
T-box transcription factor T

1

10

High-throughput

0.479

High

175053

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

17

Small-scale

0.479

High

197766

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

204195

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.479

High

211919

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

213358

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

345491

FOS
Protein c-Fos

1

11

High-throughput

0.479

High

438364

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.479

High

487596

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

505258

EGR2
E3 SUMO-protein ligase EGR2

1

12

High-throughput

0.479

High

507468

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

546008

MYOD1
Myoblast determination protein 1

1

16

High-throughput

0.479

High

553224

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

595941

HNF1A
Hepatocyte nuclear factor 1-alpha

1

20

High-throughput

0.479

High

620175

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

620385

GATA2
Endothelial transcription factor GATA-2

1

20

High-throughput

0.479

High

641482

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

651725

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

658532

TEAD1
Transcriptional enhancer factor TEF-1

1

5

High-throughput

0.479

High

679137

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

720949

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

727560

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

740556

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

782595

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

808779

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

818266

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

818819

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

822650

LHX1
LIM/homeobox protein Lhx1

1

20

High-throughput

0.479

High

831502

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.479

High

839785

LHX2
LIM/homeobox protein Lhx2

1

20

High-throughput

0.479

High

848256

HCFC1
Host cell factor 1

1

20

High-throughput

0.479

High

869494

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

877807

FOXA1
Hepatocyte nuclear factor 3-alpha

1

16

High-throughput

0.479

High

878440

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

882142

GSC
Homeobox protein goosecoid

1

17

High-throughput

0.479

High

973865

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

985239

HME1
Homeobox protein engrailed-1

1

13

High-throughput

0.479

High

988783

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

1021235

FOXI1
Forkhead box protein I1

1

16

High-throughput

0.479

High

1021323

FOXL1
Forkhead box protein L1

1

16

High-throughput

0.479

High

1042076

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1046715

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1060330

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1071055

IRF4
Interferon regulatory factor 4

1

7

High-throughput

0.479

High

1078590

SMAD2
Mothers against decapentaplegic homolog 2

1

14

Small-scale

0.479

High

1085161

TBR1
T-box brain protein 1

1

10

High-throughput

0.479

High

1176247

ASXL2
Putative Polycomb group protein ASXL2

1

20

Small-scale

0.479

High

1188580

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.479

High

1220790

ASXL1
Polycomb group protein ASXL1

1

6

Small-scale

0.479

High

1239571

KDM1B
Lysine-specific histone demethylase 2

1

10

Small-scale

0.479

High

1242603

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1243826

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1243827

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

20

High-throughput

0.479

High

1243828

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1243829

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1243830

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

Small-scale

0.479

High

1243831

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1243832

LHX4
LIM/homeobox protein Lhx4

1

20

High-throughput

0.479

High

1243834

FEV
Protein FEV

1

20

High-throughput

0.479

High

1243835

ASCL2
Achaete-scute homolog 2

1

18

Small-scale

0.479

High

1243837

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1243839

PHF20
PHD finger protein 20

1

20

High-throughput

0.479

High

1243841

ASXL3
Putative Polycomb group protein ASXL3

1

20

Small-scale

0.479

High

1243843

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1243844

GCM1
Chorion-specific transcription factor GCMa

1

3

High-throughput

0.479

High

1243847

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

1243849

LHX3
LIM/homeobox protein Lhx3

1

20

High-throughput

0.479

High

1243850

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1243851

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.479

High

1243854

HCFC2
Host cell factor 2

1

20

High-throughput

0.479

High

1243842

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.470

High

825720

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

1243845

GRHL1
Grainyhead-like protein 1 homolog

1

5

High-throughput

0.445

High

1135414

WLS
Protein wntless homolog

1

0

Small-scale

0.438

High

100975

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1053608

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024