HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DOK6 (Q6PKX4)
Docking protein 6 (Downstream of tyrosine kinase 6)
Gene: DOK6

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 331
+	Hs
		338739 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK4_HUMAN (1-316): 7.87e-122: 354: 63.50
+	Hs
		339065 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK5_HUMAN (1-307): 1.22e-117: 343: 70.13
+	Mm
		250953 EGFR_MOUSE (1-1210): 0: 1258: 90.35		DOK2_MOUSE (8-329): 6.29e-80: 250: 20.29
+	Hs
		338036 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS1_HUMAN (2-329): 4.83e-80: 266: 18.58
+	Hs
		383858 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK6_HUMAN (1-331): 5.98e-138: 396: 100.00
+	Hs
		338891 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK1_HUMAN (6-313): 1.36e-81: 257: 20.06
+	Hs
		235032 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK2_HUMAN (6-329): 2.94e-81: 254: 21.05
+	Hs
		339187 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS2_HUMAN (8-321): 9.56e-68: 232: 18.37
+	Hs
		151678 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS4_HUMAN (6-269): 5.75e-65: 224: 19.33
+	Hs
		383894 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK4_HUMAN (1-316): 7.87e-122: 354: 63.50
+	Hs
		338618 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK3_HUMAN (9-325): 7.01e-68: 222: 18.55
+	Hs
		338745 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00
+	Hs
		383652 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS1_HUMAN (2-329): 4.83e-80: 266: 18.58
+	Hs
		383949 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK1_HUMAN (6-313): 1.36e-81: 257: 20.06
+	Hs
		151685 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS4_HUMAN (6-269): 5.75e-65: 224: 19.33
+	Hs
		207289 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FRS3_HUMAN (126-321): 1.01e-42: 155: 22.17
+	Hs
		434219 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK6_HUMAN (1-331): 5.98e-138: 396: 100.00
+	Hs
		434248 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK4_HUMAN (1-316): 7.87e-122: 354: 63.50
+	Hs
		235038 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK2_HUMAN (6-329): 2.94e-81: 254: 21.05
+	Hs
		434249 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00