Protein: MYOC
Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]

Gene: MYOC
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q99972

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding
GO:0005109 - frizzled binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1408442

MYOC
Myocilin

2

10

Small-scale

0.793

High

1399522

NOE3
Noelin-3

1

10

Small-scale

0.692

High

1408443

OLFL3
Olfactomedin-like protein 3

1

10

Small-scale

0.621

High

226869

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

1

High-throughput

0.553

High

482697

SPRC
SPARC

1

3

Small-scale

0.552

High

1127556

SPRL1
SPARC-like protein 1

1

3

Small-scale

0.552

High

409056

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.504

High

389496

FINC
Fibronectin

1

1

Small-scale

0.501

High

402669

ALDOA
Fructose-bisphosphate aldolase A

1

1

Small-scale

0.501

High

446027

ENOA
Alpha-enolase

1

2

Small-scale

0.501

High

772296

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

2

Small-scale

0.501

High

534000

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

1

Small-scale

0.483

High

183294

LAMA5
Laminin subunit alpha-5

1

6

Small-scale

0.481

High

384290

CO3A1

1

1

Small-scale

0.481

High

388736

C1QB
Complement C1q subcomponent subunit B

1

4

Small-scale

0.481

High

445674

KCRM
Creatine kinase M-type

1

3

Small-scale

0.481

High

465978

CO1A2
Collagen alpha-2(I) chain

1

1

Small-scale

0.481

High

573224

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.481

High

586211

IGLL1
Immunoglobulin lambda-like polypeptide 1

1

2

Small-scale

0.481

High

609789

LEG3
Galectin-3

1

1

Small-scale

0.481

High

787836

PEDF
Pigment epithelium-derived factor

1

4

Small-scale

0.481

High

948919

CD81
CD81 antigen

1

6

Small-scale

0.481

High

953058

ACTB
Actin, cytoplasmic 1

1

2

Small-scale

0.481

High

977813

ACTA
Actin, aortic smooth muscle

1

2

Small-scale

0.481

High

993311

ACTG
Actin, cytoplasmic 2

1

2

Small-scale

0.481

High

1047712

NOTC2
Neurogenic locus notch homolog protein 2

1

3

Small-scale

0.481

High

456835

ANXA2
Annexin A2

1

0

Small-scale

0.480

High

712265

TKT
Transketolase

1

0

Small-scale

0.480

High

1030758

CAP1
Adenylyl cyclase-associated protein 1

1

0

Small-scale

0.480

High

131197

CLIC1
Chloride intracellular channel protein 1

1

0

Small-scale

0.460

High

369738

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.460

High

370017

TIMP1
Metalloproteinase inhibitor 1

1

0

Small-scale

0.460

High

391427

FRIL
Ferritin light chain

1

0

Small-scale

0.460

High

622670

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

0

Small-scale

0.460

High

770046

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.460

High

787446

TGFR1
TGF-beta receptor type-1

1

0

Small-scale

0.460

High

844225

ECE1
Endothelin-converting enzyme 1

1

0

Small-scale

0.460

High

996308

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.460

High

1116737

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

Small-scale

0.460

High

1162774

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

Small-scale

0.460

High

474933

VIME
Vimentin

1

0

Small-scale

0.458

High

482959

TPM1
Tropomyosin alpha-1 chain

1

0

Small-scale

0.458

High

761847

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

776851

MYH11
Myosin-11

1

0

Small-scale

0.458

High

1035869

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

1272732

MAEA
E3 ubiquitin-protein transferase MAEA

1

0

Small-scale

0.251

Low

1382828

FUBP1
Far upstream element-binding protein 1

1

0

Small-scale

0.251

Low

613162

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025