HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: NFXL1 (Q6ZNB6)
NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP)
Gene: NFXL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 911
+	Hs
		337952 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENA_HUMAN (562-857): 2.88e-29: 128: 11.30
+	Mm
		291363 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SORL_MOUSE (170-463): 8.81e-22: 104: 13.30
+	Hs
		338533 EGFR_HUMAN (1-1210): 0: 1241: 100.00		EYS_HUMAN (114-455): 9.25e-17: 88.1: 13.58
+	Hs
		338326 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRP1_HUMAN (518-840): 1.73e-12: 74.2: 10.70
+	Hs
		338310 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NOTC2_HUMAN (187-595): 1.64e-10: 67.3: 13.65
+	Mm
		291362 ERBB2_MOUSE (5-1200): 0: 1116: 48.46		SORL_MOUSE (170-463): 8.81e-22: 104: 13.30
+	Hs
		383909 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SORL_HUMAN (170-463): 1.19e-21: 103: 12.72
+	Hs
		601966 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		SORL_HUMAN (170-463): 1.19e-21: 103: 12.72
+	Mm
		291364 EPHA4_MOUSE (660-1016): 1.38e-120: 399: 31.52		SORL_MOUSE (170-463): 8.81e-22: 104: 13.30
+	Hs
		434176 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NOTC2_HUMAN (187-595): 1.64e-10: 67.3: 13.65
+	Hs
		434309 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NOTC3_HUMAN (608-855): 9.4e-09: 61.9: 10.18
+	Mm
		291359 INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65		SORL_MOUSE (170-463): 8.81e-22: 104: 13.30
+	Dm
		422748 Q0KIF4_DROME (621-1017): 1.89e-113: 382: 32.07		NOTCH_DROME (174-742): 1.2e-17: 90.8: 11.27
+	Hs
		872634 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		NOTC2_HUMAN (187-595): 1.64e-10: 67.3: 13.65
+	Hs
		665584 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		NOTC2_HUMAN (187-595): 1.64e-10: 67.3: 13.65
+	Hs
		980379 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		NOTC2_HUMAN (187-595): 1.64e-10: 67.3: 13.65
+	Rn
		102570 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		LRP1_RAT (482-836): 6.5e-10: 65.7: 12.67
+	Hs
		796553 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		LRP1_HUMAN (518-840): 1.73e-12: 74.2: 10.70