Protein: RAGP1
Ran GTPase-activating protein 1 (RanGAP1)

Gene: RAGP1, RANGAP1
Organism: Homo sapiens
Interactions: 224
UniProt ID: P46060

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0003723 - RNA binding
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

801676

UBC9
SUMO-conjugating enzyme UBC9

29

7

Small-scale

0.993

High

801793

SENP1
Sentrin-specific protease 1

7

3

Small-scale

0.966

High

801666

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

3

High-throughput

0.811

High

801780

SENP2
Sentrin-specific protease 2

2

3

Small-scale

0.778

High

801672

RAN
GTP-binding nuclear protein Ran

9

8

Small-scale

0.753

High

801656

RBP2
E3 SUMO-protein ligase RanBP2

9

1

Small-scale

0.750

High

801674

SUMO1
Small ubiquitin-related modifier 1

8

5

Small-scale

0.749

High

801730

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.737

High

270380

KS6A5
Ribosomal protein S6 kinase alpha-5

1

1

High-throughput

0.691

High

801657

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.691

High

801752

AURKB
Aurora kinase B

1

2

High-throughput

0.691

High

801795

NLK
Serine/threonine-protein kinase NLK

1

5

High-throughput

0.691

High

578389

RCC1
Regulator of chromosome condensation

3

1

High-throughput

0.667

High

801695

IMB1
Importin subunit beta-1

3

4

Small-scale

0.667

High

162482

XPO1
Exportin-1

3

6

Small-scale

0.656

High

414810

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.647

High

625206

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.647

High

801678

CSK21
Casein kinase II subunit alpha

1

5

Small-scale

0.647

High

801748

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

2

Small-scale

0.647

High

226781

PRKN
E3 ubiquitin-protein ligase parkin

3

15

High-throughput

0.640

High

147056

NEMP1
Nuclear envelope integral membrane protein 1

2

1

High-throughput

0.628

High

801796

NXF1
Nuclear RNA export factor 1

3

2

Small-scale

0.624

High

791362

HD
Huntingtin

2

2

High-throughput

0.621

High

148503

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.618

High

232803

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

20

High-throughput

0.618

High

384449

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

801652

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.618

High

801653

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.618

High

801665

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.618

High

801669

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.618

High

801667

SUMO2
Small ubiquitin-related modifier 2

2

5

High-throughput

0.594

High

685836

ARRB2
Beta-arrestin-2

2

0

Small-scale

0.585

High

801661

NU107
Nuclear pore complex protein Nup107

2

0

High-throughput

0.585

High

778975

CCNF
Cyclin-F

2

3

High-throughput

0.584

High

801671

H4
Histone H4

2

2

High-throughput

0.584

High

801649

RAGP1
Ran GTPase-activating protein 1

1

19

Small-scale

0.575

High

801686

STK4
Serine/threonine-protein kinase 4

1

5

High-throughput

0.575

High

801711

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

801741

DEP1B
DEP domain-containing protein 1B

2

2

High-throughput

0.571

High

401596

JUN
Transcription factor Jun

1

2

High-throughput

0.554

High

354356

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.553

High

801701

ARHG6
Rho guanine nucleotide exchange factor 6

2

0

High-throughput

0.547

High

801757

RHG07
Rho GTPase-activating protein 7

1

2

High-throughput

0.541

High

126442

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.536

High

134847

IMA3
Importin subunit alpha-3

1

3

High-throughput

0.536

High

312203

IPO7
Importin-7

1

2

High-throughput

0.536

High

483384

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

4

High-throughput

0.536

High

506539

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.536

High

595130

LMNB1
Lamin-B1

1

6

High-throughput

0.536

High

608506

H1T
Histone H1t

1

4

High-throughput

0.536

High

675132

CLIP1
CAP-Gly domain-containing linker protein 1

1

3

High-throughput

0.536

High

739020

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

796702

RANG
Ran-specific GTPase-activating protein

1

4

High-throughput

0.536

High

801651

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

801655

NU153
Nuclear pore complex protein Nup153

1

8

High-throughput

0.536

High

801668

NTF2
Nuclear transport factor 2

1

4

High-throughput

0.536

High

801670

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.536

High

801685

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

801692

MTMR3
Myotubularin-related protein 3

1

2

High-throughput

0.536

High

801696

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.536

High

801710

CCD93
Coiled-coil domain-containing protein 93

1

2

High-throughput

0.536

High

801713

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.536

High

801747

TNPO1
Transportin-1

1

4

High-throughput

0.536

High

801750

SEH1
Nucleoporin SEH1

1

3

High-throughput

0.536

High

801764

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

801765

LZTS2
Leucine zipper putative tumor suppressor 2

1

5

High-throughput

0.536

High

801770

FOXQ1
Forkhead box protein Q1

1

4

High-throughput

0.536

High

801772

XPO4
Exportin-4

1

5

High-throughput

0.536

High

801775

KDM4C
Lysine-specific demethylase 4C

1

2

High-throughput

0.536

High

801782

ZCC17
Zinc finger CCHC domain-containing protein 17

1

1

High-throughput

0.536

High

801783

NXT2
NTF2-related export protein 2

1

4

High-throughput

0.536

High

801784

TF7L2
Transcription factor 7-like 2

1

6

High-throughput

0.536

High

801798

FOXJ3
Forkhead box protein J3

1

4

High-throughput

0.536

High

801800

AXIN2
Axin-2

1

0

High-throughput

0.518

High

801790

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.517

High

147493

SOCS6
Suppressor of cytokine signaling 6

1

5

High-throughput

0.515

High

801704

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

High-throughput

0.515

High

801746

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.515

High

255067

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

440402

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

452670

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

801654

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

801677

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.513

High

801681

CTSL2
CTD small phosphatase-like protein 2

1

0

High-throughput

0.513

High

801682

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

801691

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

801707

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

801738

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

801744

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.513

High

801762

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

174699

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

801663

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

801749

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

9

Small-scale

0.501

High

801755

NDF6
Neurogenic differentiation factor 6

1

0

High-throughput

0.493

High

801787

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.493

High

801791

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.493

High

801703

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.489

High

444683

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

High-throughput

0.481

High

528247

CCL5
C-C motif chemokine 5

1

1

High-throughput

0.481

High

801673

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

High-throughput

0.481

High

801766

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

199538

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

3

Small-scale

0.479

High

209750

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

233273

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

294495

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

304059

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

Small-scale

0.479

High

322301

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

338099

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

346174

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

359739

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.479

High

386273

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

391589

H2A1B
Histone H2A type 1-B/E

1

10

High-throughput

0.479

High

455192

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

496515

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

503628

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

521789

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

801739

BICD2
Protein bicaudal D homolog 2

1

5

High-throughput

0.479

High

552162

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

555338

H2AX
Histone H2AX

1

11

High-throughput

0.479

High

569351

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

650599

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

668500

PML
Protein PML

1

11

High-throughput

0.479

High

684489

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

718379

PCGF2
Polycomb group RING finger protein 2

1

4

Small-scale

0.479

High

719903

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

727219

NU214
Nuclear pore complex protein Nup214

1

3

Small-scale

0.479

High

749198

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

759546

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

799057

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

799936

VDAC2
Voltage-dependent anion-selective channel protein 2

1

2

High-throughput

0.479

High

801650

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

801662

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

801664

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.479

High

801679

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

801684

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

801688

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

801689

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

801690

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

801693

CUL3
Cullin-3

1

10

High-throughput

0.479

High

801694

TRI14
Tripartite motif-containing protein 14

1

20

High-throughput

0.479

High

801697

CUL7
Cullin-7

1

1

High-throughput

0.479

High

801698

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

801699

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

801700

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

801702

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

801706

PCBP1
Poly(rC)-binding protein 1

1

4

Small-scale

0.479

High

801708

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

801709

FBX43
F-box only protein 43

1

1

Small-scale

0.479

High

801712

DDI2
Protein DDI1 homolog 2

1

3

High-throughput

0.479

High

801715

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

801719

RHG36
Rho GTPase-activating protein 36

1

1

High-throughput

0.479

High

801720

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

801721

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.479

High

801722

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

801723

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

801725

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

801727

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

Small-scale

0.479

High

801728

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.479

High

801743

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

801745

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

801753

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

801759

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

801760

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

801761

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

High-throughput

0.479

High

801763

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.479

High

801769

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

801773

WWTR1
WW domain-containing transcription regulator protein 1

1

3

High-throughput

0.479

High

801776

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

801777

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

801778

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.479

High

801781

MYO10
Unconventional myosin-X

1

1

Small-scale

0.479

High

801785

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

801786

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

801789

SALL1
Sal-like protein 1

1

1

High-throughput

0.479

High

801797

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

801799

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

801802

TRAF6
TNF receptor-associated factor 6

1

19

High-throughput

0.479

High

255576

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

351297

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

417184

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

615670

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

742114

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

744382

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

790643

WASP
Actin nucleation-promoting factor WAS

1

0

Small-scale

0.458

High

801658

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.458

High

801675

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

801680

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

801687

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

801716

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

801717

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

801726

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

801729

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

801736

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

801737

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

801742

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

801756

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

801768

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.458

High

801788

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

Small-scale

0.458

High

801792

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

801794

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

801801

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

801659

SUMO3
Small ubiquitin-related modifier 3

1

5

Small-scale

0.445

High

801718

NBEL2
Neurobeachin-like protein 2

1

1

High-throughput

0.445

High

801731

PALS1
Protein PALS1

1

1

High-throughput

0.445

High

801771

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

801660

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.437

High

801724

CLC14
C-type lectin domain family 14 member A

1

1

Small-scale

0.437

High

801732

ARG39
Rho guanine nucleotide exchange factor 39

1

1

High-throughput

0.437

High

801740

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.437

High

801774

DJC25
DnaJ homolog subfamily C member 25

1

3

High-throughput

0.437

High

48632

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

801751

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

801754

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

801758

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

801683

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.407

High

801705

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.282

High

274957

RENR
Renin receptor

1

0

High-throughput

0.279

Low

801735

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

801714

USPL1
SUMO-specific isopeptidase USPL1

1

0

Small-scale

0.261

Low

801733

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

801767

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.249

Low

801779

LFG4
Protein lifeguard 4

1

0

High-throughput

0.249

Low

801734

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024