HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DOCK4 (Q8N1I0)
Dedicator of cytokinesis protein 4
Gene: DOCK4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25754235, 18271526
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1966
+	Rn
		94333 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		F1M4N6_RAT (1-1964): 0: 1866: 54.51
+	Mm
		796511 ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00		DOCK2_MOUSE (2-1771): 0: 1827: 35.73
+	Hs
		983610 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		DOCK1_HUMAN (2-1792): 0: 1798: 36.67
+	Hs
		338819 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOC10_HUMAN (976-1630): 7.7e-156: 533: 15.01
+	Hs
		383938 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOCK7_HUMAN (699-1065): 1.41e-60: 233: 11.77
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (1657-1963): 2.99e-17: 90.6: 12.42
+	Hs
		601979 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DOCK7_HUMAN (699-1065): 1.41e-60: 233: 11.77
+	Hs
		339003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS1_HUMAN (1564-1964): 3.26e-11: 71.3: 17.78
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (1657-1963): 2.99e-17: 90.6: 12.42
+	Hs
		1071015 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS1_HUMAN (1564-1964): 3.26e-11: 71.3: 17.78
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (1657-1963): 2.99e-17: 90.6: 12.42
+	Hs
		383987 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TENS1_HUMAN (1564-1964): 3.26e-11: 71.3: 17.78
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (1657-1963): 2.99e-17: 90.6: 12.42
+	Hs
		602002 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TENS1_HUMAN (1564-1964): 3.26e-11: 71.3: 17.78
+	Mm
		56977 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		A2A9M5_MOUSE (699-1065): 7.41e-61: 234: 12.01
+	Hs
		554283 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		MUC1_HUMAN (1657-1963): 2.99e-17: 90.6: 12.42