HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24797263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0032587 - ruffle membrane GO:0032991 - protein-containing complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 986
+	Hs
		383913 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		339059 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (142-598): 5.92e-82: 285: 18.26
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (142-680): 2.9e-85: 293: 15.54
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (222-600): 5.07e-70: 257: 22.28
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (222-599): 8.01e-67: 247: 22.90
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49
+	Hs
		383705 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46
+	Hs
		384022 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (224-886): 6.14e-74: 270: 11.89
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54
+	Hs
		383927 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q96D37_HUMAN (142-680): 2.9e-85: 293: 15.54
+	Hs
		548637 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54