Protein: CBX4
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)

Gene: CBX4
Organism: Homo sapiens
Interactions: 233
UniProt ID: O00257

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0003727 - single-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

129671

BMI1
Polycomb complex protein BMI-1

17

20

Small-scale

0.985

High

129723

RING1
E3 ubiquitin-protein ligase RING1

10

20

Small-scale

0.976

High

129792

RING2
E3 ubiquitin-protein ligase RING2

8

20

Small-scale

0.973

High

129672

PCGF2
Polycomb group RING finger protein 2

10

20

Small-scale

0.972

High

129809

CBX8
Chromobox protein homolog 8

5

16

Small-scale

0.922

High

129801

PCGF6
Polycomb group RING finger protein 6

4

20

High-throughput

0.909

High

129730

CBX2
Chromobox protein homolog 2

4

17

Small-scale

0.873

High

129796

PCGF1
Polycomb group RING finger protein 1

3

20

Small-scale

0.861

High

129739

PCGF3
Polycomb group RING finger protein 3

3

20

High-throughput

0.847

High

129715

H33
Histone H3.3

3

20

Small-scale

0.843

High

129615

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

20

Small-scale

0.836

High

129821

KDM5B
Lysine-specific demethylase 5B

2

4

Small-scale

0.806

High

129610

CBX4
E3 SUMO-protein ligase CBX4

2

16

Small-scale

0.802

High

129628

CBX6
Chromobox protein homolog 6

2

17

High-throughput

0.789

High

129756

PCGF5
Polycomb group RING finger protein 5

2

20

High-throughput

0.789

High

129710

H31
Histone H3.1

2

20

Small-scale

0.783

High

129713

PHC1
Polyhomeotic-like protein 1

10

20

Small-scale

0.754

High

129727

CTBP1
C-terminal-binding protein 1

9

5

Small-scale

0.751

High

129736

H31T
Histone H3.1t

2

20

Small-scale

0.738

High

129763

PHC2
Polyhomeotic-like protein 2

6

20

Small-scale

0.735

High

129773

PHC3
Polyhomeotic-like protein 3

6

20

Small-scale

0.729

High

129835

DNM3A
DNA

1

9

Small-scale

0.724

High

129697

1433G
14-3-3 protein gamma

5

8

High-throughput

0.709

High

129722

1433F
14-3-3 protein eta

5

8

High-throughput

0.709

High

129737

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

129811

HELLS
Lymphoid-specific helicase

1

20

High-throughput

0.691

High

129660

1433T
14-3-3 protein theta

4

8

High-throughput

0.691

High

129752

H32
Histone H3.2

1

20

Small-scale

0.680

High

129708

CSK2B
Casein kinase II subunit beta

3

4

Small-scale

0.674

High

129709

CSK21
Casein kinase II subunit alpha

3

10

Small-scale

0.671

High

129651

CSK22
Casein kinase II subunit alpha'

3

10

Small-scale

0.667

High

129751

BCOR
BCL-6 corepressor

3

20

Small-scale

0.667

High

129666

1433B
14-3-3 protein beta/alpha

3

8

Small-scale

0.660

High

129719

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.647

High

129726

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

Small-scale

0.647

High

129783

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

10

Small-scale

0.640

High

129771

KCD17
BTB/POZ domain-containing protein KCTD17

4

4

High-throughput

0.630

High

129705

1433Z
14-3-3 protein zeta/delta

2

8

High-throughput

0.621

High

129635

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.618

High

129669

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

129701

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

129706

SUMO1
Small ubiquitin-related modifier 1

2

5

Small-scale

0.611

High

129787

SCMH1
Polycomb protein SCMH1

2

20

High-throughput

0.611

High

66683

ARI3C
AT-rich interactive domain-containing protein 3C

2

4

High-throughput

0.606

High

129650

RO52
E3 ubiquitin-protein ligase TRIM21

2

7

High-throughput

0.606

High

129622

PR40A
Pre-mRNA-processing factor 40 homolog A

2

1

High-throughput

0.601

High

129735

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.597

High

129716

SATB1
DNA-binding protein SATB1

2

1

Small-scale

0.595

High

129698

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.595

High

129621

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

129641

RB
Retinoblastoma-associated protein

2

10

Small-scale

0.584

High

129686

ZN131
Zinc finger protein 131

2

20

Small-scale

0.584

High

129700

H4
Histone H4

2

15

High-throughput

0.584

High

129712

GTF2I
General transcription factor II-I

2

2

Small-scale

0.584

High

129733

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

129740

DCAF6
DDB1- and CUL4-associated factor 6

2

14

High-throughput

0.584

High

129766

SLX4
Structure-specific endonuclease subunit SLX4

2

7

High-throughput

0.584

High

129618

ZEB2
Zinc finger E-box-binding homeobox 2

1

20

Small-scale

0.578

High

117239

K7EK07
Histone H3

1

20

High-throughput

0.575

High

129720

ERCC6
DNA excision repair protein ERCC-6

1

20

High-throughput

0.575

High

129816

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

High-throughput

0.575

High

129738

KLH40
Kelch-like protein 40

2

4

High-throughput

0.574

High

129784

VWCE
von Willebrand factor C and EGF domain-containing protein

2

4

High-throughput

0.574

High

129632

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

129667

1433S
14-3-3 protein sigma

2

8

High-throughput

0.571

High

129823

MBD1
Methyl-CpG-binding domain protein 1

1

20

Small-scale

0.561

High

129808

FBRS
Probable fibrosin-1

2

6

High-throughput

0.558

High

129691

CTBP2
C-terminal-binding protein 2

1

5

Small-scale

0.552

High

129630

WIZ
Protein Wiz

1

20

High-throughput

0.536

High

129654

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

129679

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.536

High

129687

TXTP
Tricarboxylate transport protein, mitochondrial

1

7

High-throughput

0.536

High

129695

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.536

High

129707

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.536

High

129724

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

129759

TSYL5
Testis-specific Y-encoded-like protein 5

1

4

High-throughput

0.536

High

129761

KMT5C
Histone-lysine N-methyltransferase KMT5C

1

3

High-throughput

0.536

High

129774

KDM2B
Lysine-specific demethylase 2B

1

10

High-throughput

0.536

High

129795

TBA1C
Tubulin alpha-1C chain

1

9

High-throughput

0.536

High

129819

FBLN5
Fibulin-5

1

2

High-throughput

0.536

High

129826

SCML1
Sex comb on midleg-like protein 1

1

20

High-throughput

0.536

High

129832

KDM2A
Lysine-specific demethylase 2A

1

13

High-throughput

0.536

High

129637

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.515

High

129647

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.515

High

129702

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.515

High

129619

CCNT1
Cyclin-T1

1

0

High-throughput

0.513

High

129620

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.513

High

129655

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.513

High

129743

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.513

High

129785

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

129818

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

129611

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.493

High

129662

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

129689

CASP6
Caspase-6

1

0

High-throughput

0.493

High

125814

AP4M1
AP-4 complex subunit mu-1

1

1

High-throughput

0.489

High

129692

MYL6
Myosin light polypeptide 6

1

1

High-throughput

0.489

High

129742

CD158
Coiled-coil domain-containing protein 158

1

2

High-throughput

0.489

High

129789

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

1

High-throughput

0.489

High

129794

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.489

High

129822

S18L2
SS18-like protein 2

1

1

High-throughput

0.489

High

129824

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

129834

PCDBB
Protocadherin beta-11

1

11

High-throughput

0.489

High

129646

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

129617

SPOP
Speckle-type POZ protein

1

5

Small-scale

0.481

High

129631

ZBED1
E3 SUMO-protein ligase ZBED1

1

1

Small-scale

0.481

High

129652

MX1
Interferon-induced GTP-binding protein Mx1

1

1

Small-scale

0.481

High

129668

STIP1
Stress-induced-phosphoprotein 1

1

1

Small-scale

0.481

High

129782

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

128599

MEN1
Menin

1

1

High-throughput

0.479

High

129612

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

129614

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

5

High-throughput

0.479

High

129623

EED
Polycomb protein EED

1

17

High-throughput

0.479

High

129624

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

5

High-throughput

0.479

High

129627

TOX4
TOX high mobility group box family member 4

1

19

High-throughput

0.479

High

129629

EYA4
Protein phosphatase EYA4

1

7

High-throughput

0.479

High

129633

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

129634

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

129638

JUN
Transcription factor Jun

1

9

High-throughput

0.479

High

129642

NPM
Nucleophosmin

1

3

High-throughput

0.479

High

129643

NFIC
Nuclear factor 1 C-type

1

19

High-throughput

0.479

High

129644

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

129645

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.479

High

129649

EGR1
Early growth response protein 1

1

20

High-throughput

0.479

High

129657

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

129658

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

129659

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

129663

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.479

High

129664

PML
Protein PML

1

20

High-throughput

0.479

High

129674

SYUA
Alpha-synuclein

1

1

Small-scale

0.479

High

129675

COIL
Coilin

1

2

High-throughput

0.479

High

129676

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

129678

YAP1
Transcriptional coactivator YAP1

1

1

Small-scale

0.479

High

129680

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.479

High

129682

RBM25
RNA-binding protein 25

1

5

High-throughput

0.479

High

129683

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

129684

MECP2
Methyl-CpG-binding protein 2

1

16

High-throughput

0.479

High

129685

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

8

Small-scale

0.479

High

129688

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

129690

SUMO3
Small ubiquitin-related modifier 3

1

5

Small-scale

0.479

High

129693

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.479

High

129694

SUMO2
Small ubiquitin-related modifier 2

1

5

Small-scale

0.479

High

129696

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

7

Small-scale

0.479

High

129699

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

129703

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

129704

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

129711

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

129717

CENPE
Centromere-associated protein E

1

2

High-throughput

0.479

High

129721

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

129725

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

129728

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.479

High

129731

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

129732

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

129734

NONO
Non-POU domain-containing octamer-binding protein

1

5

High-throughput

0.479

High

129748

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

129750

WDR82
WD repeat-containing protein 82

1

17

High-throughput

0.479

High

129754

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.479

High

129760

DDX42
ATP-dependent RNA helicase DDX42

1

3

High-throughput

0.479

High

129762

MGAP
MAX gene-associated protein

1

10

High-throughput

0.479

High

129764

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

129765

YAF2
YY1-associated factor 2

1

12

High-throughput

0.479

High

129768

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

15

Small-scale

0.479

High

129770

RYBP
RING1 and YY1-binding protein

1

12

High-throughput

0.479

High

129772

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.479

High

129778

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

3

High-throughput

0.479

High

129779

ATX2L
Ataxin-2-like protein

1

7

High-throughput

0.479

High

129780

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.479

High

129781

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

129791

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

3

High-throughput

0.479

High

129798

RBM4
RNA-binding protein 4

1

3

Small-scale

0.479

High

129800

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

16

Small-scale

0.479

High

129802

NSRP1
Nuclear speckle splicing regulatory protein 1

1

6

High-throughput

0.479

High

129803

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

5

High-throughput

0.479

High

129804

HIPK2
Homeodomain-interacting protein kinase 2

1

4

Small-scale

0.479

High

129812

MDN1
Midasin

1

1

Small-scale

0.479

High

129813

DCA13
DDB1- and CUL4-associated factor 13

1

10

High-throughput

0.479

High

129814

DDX56
Probable ATP-dependent RNA helicase DDX56

1

6

High-throughput

0.479

High

129815

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

1

20

High-throughput

0.479

High

129820

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

129830

SCML2
Sex comb on midleg-like protein 2

1

20

Small-scale

0.479

High

129833

KDM3A
Lysine-specific demethylase 3A

1

15

High-throughput

0.479

High

129836

MORC2
ATPase MORC2

1

3

Small-scale

0.479

High

129653

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.470

High

129673

CBS
Cystathionine beta-synthase

1

0

Small-scale

0.460

High

129616

E41L2
Band 4.1-like protein 2

1

0

High-throughput

0.458

High

129741

FA76B
Protein FAM76B

1

0

High-throughput

0.458

High

129747

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

129753

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

129793

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

129807

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

129625

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

16

High-throughput

0.445

High

129636

ADT2
ADP/ATP translocase 2

1

5

High-throughput

0.445

High

129648

FER
Tyrosine-protein kinase Fer

1

6

High-throughput

0.445

High

129677

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.445

High

129681

CENPF
Centromere protein F

1

10

High-throughput

0.445

High

129718

H11
Histone H1.1

1

15

High-throughput

0.445

High

129744

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

2

High-throughput

0.445

High

129746

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

129758

ZN546
Zinc finger protein 546

1

20

High-throughput

0.445

High

129776

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

5

High-throughput

0.445

High

129790

SMG1
Serine/threonine-protein kinase SMG1

1

3

High-throughput

0.445

High

129799

RNF17
RING finger protein 17

1

2

High-throughput

0.445

High

129805

KDM4C
Lysine-specific demethylase 4C

1

10

Small-scale

0.445

High

129810

MOV10
Helicase MOV-10

1

4

High-throughput

0.445

High

129829

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.445

High

129831

RUVB2
RuvB-like 2

1

2

High-throughput

0.445

High

129769

LNX2
Ligand of Numb protein X 2

1

4

Small-scale

0.439

High

129613

TRNK1
TPR and ankyrin repeat-containing protein 1

1

1

High-throughput

0.437

High

129670

SDC2
Syndecan-2

1

1

High-throughput

0.437

High

129729

SRC8
Src substrate cortactin

1

2

High-throughput

0.437

High

129745

RN213
E3 ubiquitin-protein ligase RNF213

1

2

High-throughput

0.437

High

129767

DI3L2
DIS3-like exonuclease 2

1

2

High-throughput

0.437

High

129775

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.437

High

129806

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

129817

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

129827

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.437

High

129828

ANR26
Ankyrin repeat domain-containing protein 26

1

5

High-throughput

0.437

High

129777

MDM1
Nuclear protein MDM1

1

0

High-throughput

0.426

High

95933

E7ESK6
Syndecan

1

1

High-throughput

0.407

High

129825

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

3

High-throughput

0.407

High

129656

LAMA1
Laminin subunit alpha-1

1

0

High-throughput

0.279

Low

129661

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.279

Low

129714

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

129749

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

129755

RM55
Large ribosomal subunit protein mL55

1

0

High-throughput

0.279

Low

129788

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

129639

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

129640

GELS
Gelsolin

1

0

High-throughput

0.268

Low

129665

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

129757

RN180
E3 ubiquitin-protein ligase RNF180

1

0

Small-scale

0.249

Low

129797

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.249

Low

129626

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.232

Low

129786

STALP
AMSH-like protease

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025