HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0007166 - cell surface receptor signaling pathway GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 481
+	Hs
		383949 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		250953 EGFR_MOUSE (1-1210): 0: 1258: 90.35		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		338618 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		235032 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151678 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		338574 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK6_HUMAN (5-286): 8.5e-87: 271: 25.18
+	Hs
		338036 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		339065 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK5_HUMAN (5-310): 8.43e-82: 257: 24.38
+	Hs
		338739 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK4_HUMAN (5-288): 7.57e-81: 255: 24.65
+	Hs
		339187 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Hs
		338745 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		151685 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		383858 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK6_HUMAN (5-286): 8.5e-87: 271: 25.18
+	Hs
		383652 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		383894 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK4_HUMAN (5-288): 7.57e-81: 255: 24.65
+	Hs
		207289 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Hs
		235038 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		434219 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK6_HUMAN (5-286): 8.5e-87: 271: 25.18
+	Hs
		434248 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK4_HUMAN (5-288): 7.57e-81: 255: 24.65
+	Hs
		434249 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09