HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31340145, 32694521
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 922
+	Hs
		338840 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		1071010 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		338861 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		1070998 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		338105 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		601974 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		601981 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808132 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		601847 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		338634 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Hs
		339005 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		338999 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		339072 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11
+	Hs
		383984 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		434157 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		125405 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		992601 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808104 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		992607 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		992589 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		HECW1_HUMAN (163-530): 4.01e-13: 76.1: 18.40