HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	25402006, 24658140, 22973453, unassigned2173
Identification Methods	two hybrid, protein complementation assay, pull down, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 261
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (13-259): 1.04e-76: 243: 31.37
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (6-259): 4.1e-79: 249: 30.92
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (33-259): 1.87e-78: 248: 32.34
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (13-259): 5.35e-77: 244: 31.37
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		338144 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLK_HUMAN (2-259): 4.45e-77: 243: 30.88
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (27-260): 2.98e-71: 228: 24.50
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (8-260): 7.03e-64: 211: 22.56
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (7-260): 1.36e-62: 208: 21.81
+	Hs
		338082 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXK_HUMAN (1-260): 3.18e-63: 208: 24.72
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (11-260): 3.92e-58: 201: 22.09
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (18-240): 5.46e-60: 198: 27.54
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (37-176): 3.68e-13: 68.6: 32.39