Protein: ZCHC3
Zinc finger CCHC domain-containing protein 3

Gene: ZCHC3, ZCCHC3
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q9NUD5

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437351

LN28A
Protein lin-28 homolog A

3

12

High-throughput

0.830

High

1449766

YBOX2
Y-box-binding protein 2

1

9

High-throughput

0.691

High

992989

RACK1
Small ribosomal subunit protein RACK1

4

6

High-throughput

0.691

High

1418610

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

8

High-throughput

0.667

High

1429464

PAIP1
Polyadenylate-binding protein-interacting protein 1

3

2

High-throughput

0.667

High

1090305

ELAV2
ELAV-like protein 2

3

7

High-throughput

0.662

High

1449752

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

3

1

High-throughput

0.650

High

1089575

ILF2
Interleukin enhancer-binding factor 2

3

0

High-throughput

0.638

High

1290761

ZCH18
Zinc finger CCCH domain-containing protein 18

3

0

High-throughput

0.638

High

685748

U2AF2
Splicing factor U2AF 65 kDa subunit

2

4

High-throughput

0.628

High

1314840

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

2

High-throughput

0.628

High

1252530

LN28B
Protein lin-28 homolog B

1

11

High-throughput

0.618

High

182377

WDR46
WD repeat-containing protein 46

2

4

High-throughput

0.611

High

485453

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

3

High-throughput

0.611

High

1037400

H11
Histone H1.1

2

11

High-throughput

0.611

High

1161701

IF16
Gamma-interferon-inducible protein 16

2

2

High-throughput

0.611

High

1194407

LARP7
La-related protein 7

2

13

High-throughput

0.611

High

1365683

LAR4B
La-related protein 4B

2

4

High-throughput

0.611

High

1330946

CGAS
Cyclic GMP-AMP synthase

2

0

Small-scale

0.607

High

286296

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.586

High

644090

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

3

High-throughput

0.584

High

1087579

GRSF1
G-rich sequence factor 1

2

7

High-throughput

0.584

High

1215853

RC3H1
Roquin-1

2

3

Small-scale

0.584

High

1233953

Q6ICH2
single-stranded DNA cytosine deaminase

2

3

High-throughput

0.584

High

1334983

SERB1
SERPINE1 mRNA-binding protein 1

2

2

High-throughput

0.584

High

1438036

RC3H2
Roquin-2

2

4

Small-scale

0.584

High

765923

BMI1
Polycomb complex protein BMI-1

2

2

High-throughput

0.571

High

1419401

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

8

Small-scale

0.561

High

48089

RBM47
RNA-binding protein 47

1

7

High-throughput

0.536

High

74622

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

4

High-throughput

0.536

High

256692

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

4

High-throughput

0.536

High

290755

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.536

High

301231

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.536

High

429011

RLA0
Large ribosomal subunit protein uL10

1

6

High-throughput

0.536

High

462671

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

9

High-throughput

0.536

High

521968

H14
Histone H1.4

1

11

High-throughput

0.536

High

586913

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

595612

H15
Histone H1.5

1

11

High-throughput

0.536

High

595890

H13
Histone H1.3

1

11

High-throughput

0.536

High

596381

H12
Histone H1.2

1

11

High-throughput

0.536

High

616011

RL17
Large ribosomal subunit protein uL22

1

5

High-throughput

0.536

High

655351

SFPQ
Splicing factor, proline- and glutamine-rich

1

8

High-throughput

0.536

High

809870

RS19
Small ribosomal subunit protein eS19

1

6

High-throughput

0.536

High

833204

MNDA
Myeloid cell nuclear differentiation antigen

1

2

High-throughput

0.536

High

842563

RL35
Large ribosomal subunit protein uL29

1

3

High-throughput

0.536

High

860378

RS9
Small ribosomal subunit protein uS4

1

5

High-throughput

0.536

High

959990

RS3A
Small ribosomal subunit protein eS1

1

7

High-throughput

0.536

High

979285

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.536

High

985021

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.536

High

1009335

PRR3
Proline-rich protein 3

1

1

High-throughput

0.536

High

1016638

SRSF3
Serine/arginine-rich splicing factor 3

1

15

High-throughput

0.536

High

1061173

SRSF1
Serine/arginine-rich splicing factor 1

1

14

High-throughput

0.536

High

1099273

SRSF5
Serine/arginine-rich splicing factor 5

1

12

High-throughput

0.536

High

1099566

SRSF6
Serine/arginine-rich splicing factor 6

1

17

High-throughput

0.536

High

1112197

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.536

High

1114423

CUL3
Cullin-3

1

4

High-throughput

0.536

High

1116047

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

1148803

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

9

High-throughput

0.536

High

1151213

OASL
2'-5'-oligoadenylate synthase-like protein

1

2

High-throughput

0.536

High

1160102

SRSF7
Serine/arginine-rich splicing factor 7

1

14

High-throughput

0.536

High

1178100

RN151
RING finger protein 151

1

2

High-throughput

0.536

High

1291233

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1390630

NEIL1
Endonuclease 8-like 1

1

1

High-throughput

0.536

High

1395715

ZN668
Zinc finger protein 668

1

2

High-throughput

0.536

High

1428478

REXO4
RNA exonuclease 4

1

2

High-throughput

0.536

High

1449754

NOP53
Ribosome biogenesis protein NOP53

1

3

High-throughput

0.536

High

1449756

PURG
Purine-rich element-binding protein gamma

1

1

High-throughput

0.536

High

1449757

HSPB8
Heat shock protein beta-8

1

1

High-throughput

0.536

High

1449760

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

1

High-throughput

0.536

High

1449762

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.536

High

1449765

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.536

High

1449767

RBM19
Probable RNA-binding protein 19

1

9

High-throughput

0.536

High

192649

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

1339729

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

1356139

THAP3
THAP domain-containing protein 3

1

0

High-throughput

0.513

High

1429990

SHRPN
Sharpin

1

0

High-throughput

0.513

High

1449750

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1449751

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

1449759

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1449768

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

1419543

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

3

High-throughput

0.500

High

191828

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.489

High

338983

CBX6
Chromobox protein homolog 6

1

1

High-throughput

0.489

High

502557

H2A1
Histone H2A type 1

1

4

High-throughput

0.489

High

1387901

PABP5
Polyadenylate-binding protein 5

1

6

High-throughput

0.489

High

1438652

CBX8
Chromobox protein homolog 8

1

1

High-throughput

0.489

High

141675

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

High-throughput

0.479

High

243071

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

248359

HBP1
HMG box-containing protein 1

1

1

High-throughput

0.479

High

294400

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

320086

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

345119

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.479

High

346393

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

374965

RASH
GTPase HRas

1

2

Small-scale

0.479

High

473121

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

10

High-throughput

0.479

High

550489

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.479

High

713861

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

9

High-throughput

0.479

High

954285

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

960271

RL26
Large ribosomal subunit protein uL24

1

10

High-throughput

0.479

High

1023293

RBM3
RNA-binding protein 3

1

8

Small-scale

0.479

High

1111885

TRA2A
Transformer-2 protein homolog alpha

1

6

High-throughput

0.479

High

1127189

RBM39
RNA-binding protein 39

1

6

High-throughput

0.479

High

1129517

PUM1
Pumilio homolog 1

1

3

High-throughput

0.479

High

1137542

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1155820

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1165514

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

9

High-throughput

0.479

High

1207450

HABP4
Intracellular hyaluronan-binding protein 4

1

2

High-throughput

0.479

High

1235540

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1255743

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1275708

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

High-throughput

0.479

High

1276851

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1336309

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.479

High

1367385

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1369856

CELF1
CUGBP Elav-like family member 1

1

3

High-throughput

0.479

High

1370252

DAZL
Deleted in azoospermia-like

1

6

High-throughput

0.479

High

1387849

ZBT10
Zinc finger and BTB domain-containing protein 10

1

1

Small-scale

0.479

High

1393967

FUBP3
Far upstream element-binding protein 3

1

6

High-throughput

0.479

High

1407909

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1409772

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

1

High-throughput

0.479

High

1412100

TRI56
E3 ubiquitin-protein ligase TRIM56

1

1

High-throughput

0.479

High

1420366

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.479

High

1429234

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

1

High-throughput

0.479

High

1438869

MOV10
Helicase MOV-10

1

1

High-throughput

0.479

High

1449749

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

1449753

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

6

High-throughput

0.479

High

1449755

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1449758

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1449769

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

7

High-throughput

0.479

High

326063

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

696635

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

875801

PRC2A
Protein PRRC2A

1

0

High-throughput

0.458

High

879515

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

1125240

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

Small-scale

0.458

High

1126552

CAPR1
Caprin-1

1

0

High-throughput

0.458

High

1146483

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.458

High

1252402

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1280754

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.458

High

1295581

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1351991

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

1393167

PRR11
Proline-rich protein 11

1

0

High-throughput

0.458

High

1393740

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1448202

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

73459

B2CML4
single-stranded DNA cytosine deaminase

1

3

High-throughput

0.445

High

135363

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

7

High-throughput

0.445

High

516452

CALM2
Calmodulin-2

1

2

High-throughput

0.445

High

516593

CALM3
Calmodulin-3

1

2

High-throughput

0.445

High

983414

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

5

High-throughput

0.445

High

1383333

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

3

High-throughput

0.445

High

106720

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

373267

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

406701

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.437

High

504986

H2AB2
Histone H2A-Bbd type 2/3

1

3

High-throughput

0.437

High

551288

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.437

High

589817

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

769302

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

907598

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

965270

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.437

High

971158

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1357575

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

1437221

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

1449761

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

1449763

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.437

High

1119327

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1449764

LORF1
LINE-1 retrotransposable element ORF1 protein

1

0

Small-scale

0.426

High

62601

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

72817

B0UZZ8
WD repeat-containing protein 46

1

4

High-throughput

0.407

High

1234980

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.407

High

1335746

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

868390

CDX1
Homeobox protein CDX-1

2

0

High-throughput

0.328

High

943865

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.279

Low

1099640

NOGG
Noggin

1

0

High-throughput

0.279

Low

186057

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

1126188

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1233852

GRAM4
GRAM domain-containing protein 4

1

0

Small-scale

0.249

Low

1327225

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1447318

ANLN
Anillin

1

0

High-throughput

0.249

Low

1203270

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.232

Low

1226287

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.232

Low

1288168

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low

1352095

Q8TE30
RNA-directed DNA polymerase

1

0

Small-scale

0.232

Low

1398374

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.232

Low

1400152

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025