HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LRC40 (Q9H9A6)
Leucine-rich repeat-containing protein 40
Gene: LRRC40

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24797263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 602
+	Hs
		232756 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PHLP1_HUMAN (82-555): 7.84e-25: 112: 25.00
+	Hs
		338869 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ERBIN_HUMAN (83-237): 3.33e-14: 78.2: 31.61
+	Hs
		383981 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRC40_HUMAN (1-256): 1.44e-25: 113: 21.45
+	Hs
		1071001 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRRC7_HUMAN (84-237): 4.82e-16: 84.3: 35.07
+	Hs
		1071006 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRRC1_HUMAN (41-220): 2.84e-14: 77.8: 31.11
+	Hs
		383940 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRRC7_HUMAN (84-237): 4.82e-16: 84.3: 35.07
+	Mm
		936772 ERBB2_MOUSE (5-1200): 0: 1116: 48.46		ERBIN_MOUSE (198-578): 7.52e-14: 77: 24.48
+	Hs
		383943 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ERBIN_HUMAN (83-237): 3.33e-14: 78.2: 31.61
+	Hs
		601980 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		LRRC7_HUMAN (84-237): 4.82e-16: 84.3: 35.07
+	At
		1352201 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		Y1723_ARATH (211-600): 4.93e-35: 143: 19.10
+	At
		221803 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME1_ARATH (14-265): 2.92e-34: 141: 21.62
+	At
		1341092 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME2_ARATH (6-264): 4.36e-33: 137: 21.43
+	At
		795001 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		Y1723_ARATH (211-600): 4.93e-35: 143: 19.10
+	At
		221760 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME1_ARATH (14-265): 2.92e-34: 141: 21.62
+	At
		83704 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		Y4361_ARATH (6-261): 7.37e-35: 143: 20.95
+	At
		83702 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		RGI3_ARATH (1-256): 1.6e-32: 135: 22.26
+	At
		84503 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		GSO1_ARATH (401-601): 6.52e-22: 102: 21.36
+	At
		1338064 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		RGI1_ARATH (361-600): 6.74e-20: 96.6: 19.51
+	At
		84463 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		GSO1_ARATH (401-601): 6.52e-22: 102: 21.36
+	At
		249715 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME3_ARATH (332-601): 1.66e-15: 82.3: 17.69