HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRH (Q9HD43)
Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
Gene: PTPRH

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.42	1.00	0.653

Property	Details
Experiments	28065597
Identification Methods	ubiquitin reconstruction, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane GO:0043235 - receptor complex GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1115
+	Hs
		1071017 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRH_HUMAN (13-1115): 0: 837: 100.00
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (689-1080): 3.41e-91: 312: 28.07
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (718-1080): 4.15e-86: 295: 27.88
+	Hs
		337733 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FINC_HUMAN (28-681): 4.1e-78: 285: 18.96
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (104-855): 1.08e-73: 271: 12.86
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (1-889): 6.88e-54: 208: 16.59
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (828-1085): 5.72e-48: 189: 28.46
+	Hs
		338901 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN18_HUMAN (835-1085): 3.47e-51: 189: 43.41
+	Hs
		337952 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENA_HUMAN (21-350): 4.86e-44: 177: 19.16
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (294-886): 1.66e-42: 172: 10.25
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (93-421): 1.72e-27: 123: 14.95
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (93-426): 3.39e-26: 118: 14.52
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (2-524): 3.63e-26: 118: 12.28
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (6-291): 7.27e-21: 101: 13.33
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (17-363): 3.39e-20: 99.2: 18.13
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (183-600): 8.69e-10: 65.7: 8.71
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (93-426): 3.39e-26: 118: 14.52
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (823-1080): 4.15e-25: 115: 30.22
+	Hs
		146920 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRT_HUMAN (93-426): 3.39e-26: 118: 14.52
+	Hs
		383545 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRC_HUMAN (6-291): 7.27e-21: 101: 13.33