Protein: MPP8
M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)

Gene: MPP8, MPHOSPH8
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q99549

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0000792 - heterochromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998722

H31
Histone H3.1

4

13

Small-scale

0.899

High

1405189

EHMT1
Histone-lysine N-methyltransferase EHMT1

3

14

Small-scale

0.875

High

1405207

DNM3A
DNA

2

6

Small-scale

0.812

High

1139813

SETB1
Histone-lysine N-methyltransferase SETDB1

2

20

Small-scale

0.789

High

981040

H2B1C
Histone H2B type 1-C/E/F/G/I

2

13

High-throughput

0.754

High

1042913

ERCC6
DNA excision repair protein ERCC-6

1

8

High-throughput

0.691

High

1163162

H2B2E
Histone H2B type 2-E

1

13

High-throughput

0.691

High

1260708

HECW1
E3 ubiquitin-protein ligase HECW1

1

12

High-throughput

0.691

High

1383422

ESAM
Endothelial cell-selective adhesion molecule

1

6

High-throughput

0.691

High

1405193

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.691

High

1405201

TASOR
Protein TASOR

4

1

Small-scale

0.689

High

1397723

ZN597
Zinc finger protein 597

3

2

High-throughput

0.667

High

1405195

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.622

High

1327148

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.618

High

157768

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.618

High

980195

H4
Histone H4

1

6

High-throughput

0.618

High

1017152

H33
Histone H3.3

1

13

High-throughput

0.618

High

1255209

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1405206

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.618

High

1330911

CGAS
Cyclic GMP-AMP synthase

2

3

Small-scale

0.611

High

1338168

PPHLN
Periphilin-1

2

1

Small-scale

0.594

High

1293992

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.578

High

99215

F2Z2U4
Transformation/transcription domain associated protein

1

5

High-throughput

0.575

High

1405184

MPP8
M-phase phosphoprotein 8

1

17

Small-scale

0.575

High

396782

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1388701

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

9

Small-scale

0.561

High

247158

TBCD4
TBC1 domain family member 4

1

2

High-throughput

0.536

High

604725

UBF1
Nucleolar transcription factor 1

1

13

High-throughput

0.536

High

846436

MATR3
Matrin-3

1

2

High-throughput

0.536

High

905469

HCFC1
Host cell factor 1

1

5

High-throughput

0.536

High

936672

BRPF1
Peregrin

1

6

High-throughput

0.536

High

946056

ZN121
Zinc finger protein 121

1

1

High-throughput

0.536

High

1013099

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

2

High-throughput

0.536

High

1015289

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

1059938

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

High-throughput

0.536

High

1065387

SSRP1
FACT complex subunit SSRP1

1

15

High-throughput

0.536

High

1089822

ILF3
Interleukin enhancer-binding factor 3

1

8

High-throughput

0.536

High

1121730

SAFB2
Scaffold attachment factor B2

1

10

High-throughput

0.536

High

1134040

ZN638
Zinc finger protein 638

1

3

High-throughput

0.536

High

1134691

NUMA1
Nuclear mitotic apparatus protein 1

1

17

High-throughput

0.536

High

1148465

SAFB1
Scaffold attachment factor B1

1

11

High-throughput

0.536

High

1218952

TASO2
Protein TASOR 2

1

13

High-throughput

0.536

High

1234781

ZN770
Zinc finger protein 770

1

1

High-throughput

0.536

High

1328032

RP25L
Ribonuclease P protein subunit p25-like protein

1

1

High-throughput

0.536

High

1359689

PHIP
PH-interacting protein

1

15

High-throughput

0.536

High

1405185

UTP23
rRNA-processing protein UTP23 homolog

1

2

High-throughput

0.536

High

1405194

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

2

High-throughput

0.536

High

1405197

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

1

High-throughput

0.536

High

542176

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

855187

NOP2
28S rRNA

1

0

High-throughput

0.513

High

973548

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

1013844

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.513

High

1359561

SPIR2
Protein spire homolog 2

1

0

High-throughput

0.513

High

1380475

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1394367

ZN845
Zinc finger protein 845

1

0

High-throughput

0.513

High

1405186

MCRI2
MAPK regulated corepressor interacting protein 2

1

0

High-throughput

0.513

High

1405190

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.513

High

1405192

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.513

High

1405196

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

1405200

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.513

High

1405205

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

1402275

RANB9
Ran-binding protein 9

1

5

Small-scale

0.481

High

48757

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

260352

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

372937

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

593785

PECA1
Platelet endothelial cell adhesion molecule

1

13

High-throughput

0.479

High

630004

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

765823

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.479

High

790090

ZEB1
Zinc finger E-box-binding homeobox 1

1

5

Small-scale

0.479

High

905065

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

959640

MAX
Protein max

1

15

High-throughput

0.479

High

986662

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

1034052

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.479

High

1107131

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

High-throughput

0.479

High

1134520

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

6

High-throughput

0.479

High

1161612

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1227327

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.479

High

1294068

PA24D
Cytosolic phospholipase A2 delta

1

13

High-throughput

0.479

High

1313366

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1367098

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1405187

DDA1
DET1- and DDB1-associated protein 1

1

2

High-throughput

0.479

High

1405198

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1405199

XPO7
Exportin-7

1

15

High-throughput

0.479

High

1405202

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

510020

HMN1
Humanin-like 1

1

0

Small-scale

0.460

High

1405191

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

1405204

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

65197

A6NEM2
Host cell factor 1

1

6

High-throughput

0.445

High

116443

H7BXI1
Extended synaptotagmin-2

1

7

High-throughput

0.445

High

1180751

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

1

High-throughput

0.407

High

183713

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.279

Low

944314

TMM33
Transmembrane protein 33

1

0

High-throughput

0.279

Low

1394473

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.279

Low

1405188

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low

1405203

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025