HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: IRPL2 (Q9NP60)
X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1)
Gene: IL1RAPL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 686
+	Hs
		337853 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCAM1_HUMAN (16-448): 4.21e-44: 172: 13.21
+	Hs
		338583 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG3_HUMAN (8-495): 8.86e-41: 162: 13.51
+	Hs
		237448 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TLR2_HUMAN (327-556): 2.43e-22: 104: 19.83
+	Mm
		936212 EGFR_MOUSE (1-1210): 0: 1258: 90.35		LRIG1_MOUSE (30-394): 8.23e-16: 83.7: 17.40
+	Hs
		120118 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TLR4_HUMAN (402-556): 6.2e-18: 90.2: 23.72
+	Hs
		338841 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG1_HUMAN (42-394): 8.69e-18: 90.2: 17.66
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (200-373): 4.17e-09: 62.3: 12.00
+	Hs
		1070977 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG3_HUMAN (8-495): 8.86e-41: 162: 13.51
+	Hs
		383860 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG3_HUMAN (8-495): 8.86e-41: 162: 13.51
+	Hs
		383779 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTK7_HUMAN (8-420): 9.47e-34: 140: 11.34
+	Hs
		1070999 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG1_HUMAN (42-394): 8.69e-18: 90.2: 17.66
+	Hs
		383933 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG1_HUMAN (42-394): 8.69e-18: 90.2: 17.66
+	Hs
		383893 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IGDC4_HUMAN (3-382): 1.07e-16: 86.7: 11.97
+	Hs
		383813 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		OPCM_HUMAN (127-397): 1.2e-16: 83.9: 14.89
+	Hs
		601975 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		LRIG1_HUMAN (42-394): 8.69e-18: 90.2: 17.66
+	Hs
		434185 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTK7_HUMAN (8-420): 9.47e-34: 140: 11.34
+	Hs
		434263 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		LRIG1_HUMAN (42-394): 8.69e-18: 90.2: 17.66
+	Hs
		411375 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PTK7_HUMAN (8-420): 9.47e-34: 140: 11.34
+	Mm
		724165 RET_MOUSE (420-1058): 5.27e-125: 414: 22.14		LRIG1_MOUSE (30-394): 8.23e-16: 83.7: 17.40
+	Hs
		665239 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		OPCM_HUMAN (127-397): 1.2e-16: 83.9: 14.89