HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	25402006, 24658140, 16273093, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, unspecified method, ubiquitin reconstruction, protein array, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 258
+	Hs
		146577 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (50-248): 7.06e-42: 151: 16.11
+	Mm
		222646 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SOCS5_MOUSE (59-257): 1.8e-40: 148: 25.87
+	Hs
		147370 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		147469 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS6_HUMAN (46-256): 4.63e-45: 160: 25.69
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (50-213): 3.31e-43: 155: 16.28
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (50-248): 4.89e-42: 152: 16.11
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (50-213): 7.17e-42: 151: 16.28
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (47-215): 1.32e-41: 150: 15.82
+	Hs
		256842 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS5_HUMAN (59-257): 3.09e-41: 149: 25.87
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (7-247): 8.35e-41: 149: 14.39
+	Hs
		181754 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (12-249): 1.3e-39: 145: 13.04
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21