Protein: PRAME
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)

Gene: PRAME
Organism: Homo sapiens
Interactions: 108
UniProt ID: P78395

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1007559

CUL2
Cullin-2

7

14

Small-scale

0.754

High

1007563

ELOB
Elongin-B

4

3

Small-scale

0.708

High

1007589

IFT81
Intraflagellar transport protein 81 homolog

4

4

High-throughput

0.691

High

1007562

ELOC
Elongin-C

3

3

Small-scale

0.688

High

1007573

ZN562
Zinc finger protein 562

3

2

High-throughput

0.667

High

983755

RBX1
E3 ubiquitin-protein ligase RBX1

2

4

Small-scale

0.639

High

1007602

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

3

0

High-throughput

0.638

High

1007557

FOXD4
Forkhead box protein D4

2

3

High-throughput

0.628

High

958622

CSN2
COP9 signalosome complex subunit 2

2

3

High-throughput

0.611

High

1007601

LST8
Target of rapamycin complex subunit LST8

2

2

High-throughput

0.611

High

714821

EF1D
Elongation factor 1-delta

2

0

High-throughput

0.602

High

879780

NPY2R
Neuropeptide Y receptor type 2

2

0

High-throughput

0.602

High

1007587

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

1007592

AZIN2
Antizyme inhibitor 2

2

0

High-throughput

0.602

High

1007610

FSCN3
Fascin-3

2

0

High-throughput

0.602

High

1007561

LAGE3
EKC/KEOPS complex subunit LAGE3

2

0

Small-scale

0.585

High

1007605

NOL11
Nucleolar protein 11

2

0

High-throughput

0.585

High

1007609

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

2

0

Small-scale

0.585

High

520550

RARA
Retinoic acid receptor alpha

1

3

Small-scale

0.573

High

182506

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

366408

FA12
Coagulation factor XII

1

1

High-throughput

0.536

High

1007556

FOXF2
Forkhead box protein F2

1

3

High-throughput

0.536

High

1007570

FX4L6
Forkhead box protein D4-like 6

1

3

High-throughput

0.536

High

1007572

POTEE
POTE ankyrin domain family member E

1

3

High-throughput

0.536

High

1007576

CSN6
COP9 signalosome complex subunit 6

1

3

High-throughput

0.536

High

1007579

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

2

High-throughput

0.536

High

1007580

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.536

High

1007586

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.536

High

1007595

WDR90
WD repeat-containing protein 90

1

2

High-throughput

0.536

High

1007608

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.536

High

1007618

CSN3
COP9 signalosome complex subunit 3

1

4

High-throughput

0.536

High

1007619

GPR55
G-protein coupled receptor 55

1

4

High-throughput

0.536

High

1007623

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

261487

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

486554

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

979487

H4
Histone H4

1

0

Small-scale

0.513

High

1007584

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1007590

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

1007604

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

1007612

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1007615

RDH8
Retinol dehydrogenase 8

1

0

High-throughput

0.513

High

1007616

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1007622

AMMR1
Nuclear protein AMMECR1

1

0

High-throughput

0.513

High

507822

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.501

High

1007560

KRT81
Keratin, type II cuticular Hb1

1

5

High-throughput

0.489

High

1007578

WDR86
WD repeat-containing protein 86

1

4

High-throughput

0.489

High

891934

WHR1
Winged helix repair factor 1

1

0

Small-scale

0.486

High

1007606

ZN408
Zinc finger protein 408

1

1

High-throughput

0.481

High

1007621

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

241374

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

462347

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

Small-scale

0.479

High

519936

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

543172

UBL4A
Ubiquitin-like protein 4A

1

5

Small-scale

0.479

High

574213

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

Small-scale

0.479

High

693679

RL10
Large ribosomal subunit protein uL16

1

1

Small-scale

0.479

High

729223

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

Small-scale

0.479

High

798983

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

830549

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

842724

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

Small-scale

0.479

High

861560

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

Small-scale

0.479

High

910458

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

Small-scale

0.479

High

912840

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

5

Small-scale

0.479

High

1007554

PRAME
Melanoma antigen preferentially expressed in tumors

1

15

Small-scale

0.479

High

1007558

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

1007565

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

Small-scale

0.479

High

1007567

H2A2C
Histone H2A type 2-C

1

4

Small-scale

0.479

High

1007568

H2B2E
Histone H2B type 2-E

1

2

Small-scale

0.479

High

1007582

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1007596

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1007597

PRPK
EKC/KEOPS complex subunit TP53RK

1

1

Small-scale

0.479

High

1007599

AASD1
Alanyl-tRNA editing protein Aarsd1

1

2

High-throughput

0.479

High

1007613

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1007603

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.460

High

222933

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

246528

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.458

High

413604

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

769701

RFC4
Replication factor C subunit 4

1

0

Small-scale

0.458

High

770147

RL22
Large ribosomal subunit protein eL22

1

0

Small-scale

0.458

High

851292

PRS6B
26S proteasome regulatory subunit 6B

1

0

Small-scale

0.458

High

973135

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

1004438

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1007555

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1007566

H31T
Histone H3.1t

1

0

Small-scale

0.458

High

1007583

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

1007600

CC28B
Coiled-coil domain-containing protein 28B

1

0

High-throughput

0.458

High

1007617

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1007620

TPRKB
EKC/KEOPS complex subunit TPRKB

1

0

Small-scale

0.458

High

1007564

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.445

High

1007591

UBE2F
NEDD8-conjugating enzyme UBE2F

1

0

High-throughput

0.438

High

76514

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

6

High-throughput

0.437

High

346952

BAG2
BAG family molecular chaperone regulator 2

1

1

Small-scale

0.437

High

1007571

Q6PK50
HSP90AB1 protein

1

9

High-throughput

0.437

High

1007593

Q96BE0
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.437

High

1007598

Q9BPW0
Serine/threonine-protein phosphatase

1

4

High-throughput

0.437

High

1007607

Q9HAV2
Heat shock transcription factor 1

1

1

High-throughput

0.437

High

1007614

FXL12
F-box/LRR-repeat protein 12

1

4

Small-scale

0.437

High

379501

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

1007611

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

1007575

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

289769

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

1007577

DAAM2
Disheveled-associated activator of morphogenesis 2

1

0

High-throughput

0.279

Low

1007581

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.279

Low

1007585

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1007588

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1007594

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.279

Low

1007574

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1007569

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025